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首页> 外文期刊>Journal of pharmacokinetics and biopharmaceutics >Mathematical formalism and characteristics of four basic models of indirect pharmacodynamic responses for drug infusions.
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Mathematical formalism and characteristics of four basic models of indirect pharmacodynamic responses for drug infusions.

机译：药物输注间接药效学响应的四个基本模型的数学形式主义和特征。

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摘要

Indirect response models require differential equations to describe the nonlinear inhibition or stimulation of the production or loss (kout) of the response variable. Partially integrated solutions for these models developed previously for i.v. bolus or biphasic pharmacokinetics were extended to consider drug infusions for limited or extended durations. Qualitative examination was made of the role of infusion rate and duration, type and rate of drug disposition, Imax or Smax capacity factors, IC50 or SC50 sensitivity factors, and Kout values. Properties of the response curves characterized include curve shapes, maximum or minimum response, onset rate, steady-state, and return to baseline. Some comparisons were made with behavior of i.v. bolus doses. These relationships provide both a formal and practical basis for better understanding of the time-course of basic indirect response models.
机译：间接响应模型需要微分方程来描述响应变量的产生或损失（kout）的非线性抑制或刺激。这些先前为i.v.开发的模型的部分集成解决方案。推注或双相药代动力学被扩展以考虑在有限或延长的持续时间内进行药物输注。定性检查输注速率和持续时间，药物处置类型和速率，Imax或Smax容量因子，IC50或SC50敏感性因子以及Kout值的作用。表征的响应曲线的属性包括曲线形状，最大或最小响应，起始率，稳态和返回基线。对i.v.的行为进行了一些比较。大剂量。这些关系为更好地理解基本间接响应模型的时程提供了形式和实践基础。

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