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首页> 外文期刊>British Journal of Clinical Pharmacology >Characteristics of indirect pharmacodynamic models and applications to clinical drug responses.
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Characteristics of indirect pharmacodynamic models and applications to clinical drug responses.

机译：间接药效学模型的特征及其在临床药物反应中的应用。

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摘要

This review describes four basic physiologic indirect pharmacodynamic response (IDR) models which have been proposed to characterize the pharmacodynamics of drugs that act by indirect mechanisms such as inhibition or stimulation of the production or dissipation of factors controlling the measured effect. The principles underlying IDR models and their response patterns are described. The applicability of these basic IDR models to characterize pharmacodynamic responses of diverse drugs such as inhibition of gastric acid secretion by nizatidine and stimulation of MX protein synthesis by interferon alpha-2a is demonstrated. A list of other uses of these models is provided. These models can be readily extended to accommodate additional complexities such as nonstationary or circadian baselines, equilibration delay, depletion or accumulation of a precursor pool, sigmoidicity, or other mechanisms. Indirect response models which have a logical mechanistic basis account for time-delays in many responses and are widely applicable in clinical pharmacology.
机译：这篇综述描述了四个基本的生理学间接药效学响应模型（IDR），这些模型已被提出来表征通过间接机制（例如抑制或刺激产生或耗散控制测量效应的因素）起作用的药物的药效学。描述了IDR模型的基本原理及其响应模式。这些基本的IDR模型可用于表征多种药物的药效学反应，例如尼扎替丁抑制胃酸分泌和干扰素α-2a刺激MX蛋白合成。提供了这些模型的其他用途列表。这些模型可以轻松扩展以适应其他复杂性，例如非平稳或昼夜节律的基线，平衡延迟，前体池的耗竭或积累，信号顺应性或其他机制。具有逻辑机制基础的间接响应模型可解释许多响应中的时间延迟，并且可广泛应用于临床药理学。

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