The formulation of the principle of superposition in the presence of non-compliance and its applications in multiple dose pharmacokinetics.

Wang W; Ouyang SP

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The formulation of the principle of superposition in the presence of non-compliance and its applications in multiple dose pharmacokinetics.

机译：不合规情况下叠加原理的制定及其在多剂量药代动力学中的应用。

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The principle of superposition is an important tool for studying multiple dose pharmacokinetics. In this paper, the principle of superposition in the presence of noncompliance is formulated generally as a recursive formula. With this powerful tool, we are able to provide a simple proof under general conditions for the fundamental result that steady state AUC is equal to the single-dose AUC for any concentration curve. In another application of the principle of superposition, we establish the relationship between the steady state average concentration and patient compliance index.

机译：叠加原理是研究多剂量药代动力学的重要工具。在本文中，存在不合规情况下的叠加原理通常用递归公式表示。有了这个功能强大的工具，我们就能在一般条件下为任何浓度曲线的稳态AUC等于单剂量AUC的基本结果提供简单的证明。在叠加原理的另一个应用中，我们建立了稳态平均浓度与患者依从性指标之间的关系。

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《Journal of pharmacokinetics and biopharmaceutics》 |1998年第4期|共13页
作者
Wang W; Ouyang SP;
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正文语种 eng
中图分类药学;
关键词
Drug Administration Schedule; Patient Compliance; 用药计划表; 病人依从;

机译：Drug Administration Schedule;Patient Compliance;用药计划表;病人依从;

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1. The formulation of the principle of superposition in the presence of non-compliance and its applications in multiple dose pharmacokinetics. [J] . Wang W, Ouyang SP Journal of pharmacokinetics and biopharmaceutics . 1998,第4期

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The formulation of the principle of superposition in the presence of non-compliance and its applications in multiple dose pharmacokinetics.

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