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首页> 外文期刊>Clinics and research in hepatology and gastroenterology >Association between TLR2, MTR, MTRR, XPC, TP73, TP53 genetic polymorphisms and gastric cancer: A meta-analysis
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Association between TLR2, MTR, MTRR, XPC, TP73, TP53 genetic polymorphisms and gastric cancer: A meta-analysis

机译：TLR2，MTR，MTRR，XPC，TP73，TP53基因多态性与胃癌之间的关联：一项荟萃分析

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Objective: The aim of our meta-analyses is to test the association between six genetic polymorphisms and gastric cancer. Methods: A systematic search was performed for all the available candidate genes and gastric cancer among several online databases including PubMed, Embase, Web of Science, the Cochrane Library, CNKI and Wanfang online libraries. After a comprehensive screening, a total of six genes were harvested for the current meta-analyses. These genes include TLR2 (-196 to -174 ins>del), MTR (rs1805087), MTRR (rs1801394), XPC (rs2228001), TP73 (G4C14-A4T14), and TP53 (rs1042522). Results: Altogether 49comparative studies among 11776cases and 18633controls were involved in our meta-analyses. TP53 rs1042522 polymorphism was shown to be associated with gastric cancer risk under the dominant model (P=0.02, OR=1.03, 95% CI=1.00-1.05). A subgroup meta-analysis indicated a significant association under dominant model between TP53 rs1042522 and gastric cancer in the Eastern Asians (P=0.03, OR=1.17, 95%=1.02-1.34). Conclusions: These results suggest that TP53 rs1042522 polymorphism might contribute to the susceptibility of gastric cancer under the dominant model, especially in Eastern Asians.
机译：目的：我们的荟萃分析的目的是检验六种基因多态性与胃癌之间的关系。方法：对包括PubMed，Embase，Web of Science，Cochrane图书馆，CNKI和Wanfang网上图书馆在内的几个在线数据库进行了系统搜索，查找所有可用的候选基因和胃癌。经过全面筛选后，总共收获了六个基因用于当前的荟萃分析。这些基因包括TLR2（-196至-174 ins> del），MTR（rs1805087），MTRR（rs1801394），XPC（rs2228001），TP73（G4C14-A4T14）和TP53（rs1042522）。结果：我们的荟萃分析共涉及11776例病例和18633例对照的49项比较研究。在显性模型下，TP53 rs1042522多态性与胃癌风险相关（P = 0.02，OR = 1.03，95％CI = 1.00-1.05）。亚组荟萃分析表明，在优势模型下，TP53 rs1042522与东亚人的胃癌之间存在显着相关性（P = 0.03，OR = 1.17，95％= 1.02-1.34）。结论：这些结果表明，在优势模型下，TP53 rs1042522基因多态性可能有助于胃癌的易感性，尤其是在东亚人中。

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