Immunopathogenesis and role of T cells in psoriasis.

Ghoreschi K; Weigert C; Rocken M

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Immunopathogenesis and role of T cells in psoriasis.

机译：免疫发病机制和T细胞在牛皮癣中的作用。

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Psoriasis is a T cell-dependent autoimmune disease of the skin and joints. Disease manifestation is orchestrated by proinflammatory CD4-positive T helper cells producing either interferon-gamma (Th1) or interleukin (IL)-17 (Th17). These Th1 and Th17 cells interact with dermal dendritic cells, macrophages, mast cells, and neutrophils. Together, they cause an inflammation that mainly involves interferon-gamma, tumor necrosis factor, IL-8, IL-12, IL-17, IL-19, and IL-23. New therapeutics either are directed against T cells, tumor necrosis factor, and IL-12/IL-23 or deviate immune responses into a protective IL-4-dominated Th2 phenotype.

机译：牛皮癣是皮肤和关节的T细胞依赖性自身免疫性疾病。疾病表现由促炎性CD4阳性T辅助细胞产生，产生干扰素-γ（Th1）或白介素（IL）-17（Th17）。这些Th1和Th17细胞与真皮树突状细胞，巨噬细胞，肥大细胞和嗜中性粒细胞相互作用。它们共同导致炎症，主要涉及干扰素-γ，肿瘤坏死因子，IL-8，IL-12，IL-17，IL-19和IL-23。新疗法要么针对T细胞，肿瘤坏死因子和IL-12 / IL-23，要么将免疫反应转变为保护性的IL-4为主的Th2表型。

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来源
《Clinics in dermatology》 |2007年第6期|共7页
作者
Ghoreschi K; Weigert C; Rocken M;
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正文语种 eng
中图分类皮肤病学与性病学;
关键词
Animals; Autoimmune Diseases; Cytokines; Humans; Lymphocyte Activation; Macrophages; 动物; 自身免疫疾病; 细胞活素类; 巨噬细胞; 肥大细胞; 银屑病; T淋巴细胞亚群;

机译：Animals;Autoimmune Diseases;Cytokines;Humans;Lymphocyte Activation;Macrophages;动物;自身免疫疾病;细胞活素类;巨噬细胞;肥大细胞;银屑病;T淋巴细胞亚群;

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1. Immunopathogenesis and role of T cells in psoriasis. [J] . Ghoreschi K, Weigert C, Rocken M Clinics in dermatology . 2007,第6期

机译：免疫发病机制和T细胞在牛皮癣中的作用。
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Immunopathogenesis and role of T cells in psoriasis.

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