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首页> 外文期刊>Clinics in dermatology >Pathophysiology of acute wound healing.
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Pathophysiology of acute wound healing.

机译：急性伤口愈合的病理生理学。

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摘要

Wound healing is a complex process that can be divided into at least 3 continuous and overlapping processes: an inflammatory reaction, a proliferative process leading to tissue restoration, and, eventually, tissue remodeling. Wound healing processes are strictly regulated by multiple growth factors and cytokines released at the wound site. Although the desirable final result of coordinated healing would be the formation of tissue with a similar structure and comparable functions as with intact skin, regeneration is uncommon (with notable exceptions such as early fetal healing); healing however results in a structurally and functionally satisfactory but not identical outcome. Alterations that disrupt controlled healing processes would extend tissue damage and repair. The pathobiologic states may lead to chronic or nonhealing wounds or excessive fibrosis.
机译：伤口愈合是一个复杂的过程，可以分为至少三个连续和重叠的过程：炎症反应，导致组织恢复的增殖过程，以及最终导致组织重塑。伤口愈合过程受多种生长因子和伤口部位释放的细胞因子的严格调控。尽管协调治疗的理想最终结果将是形成具有与完整皮肤相似的结构和可比的功能的组织，但再生并不常见（明显的例外，例如早期胎儿愈合）。但是，愈合会导致结构和功能上令人满意，但结果却不完全相同。破坏受控愈合过程的变更将扩大组织损伤和修复。病理生物学状态可能导致慢性或不愈合的伤口或过度纤维化。

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