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首页> 外文期刊>Clinics in dermatology >Autoimmune collagen vascular diseases: Kids are not just little people
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Autoimmune collagen vascular diseases: Kids are not just little people

机译：自身免疫性胶原血管疾病：孩子不只是小矮人

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Morphea, dermatomyositis (DM), and discoid lupus erythematosus (DLE) are autoimmune collagen vascular diseases that can present at any age. In all three of these diseases, the tenants of diagnosis and treatment are largely the same in both children and adults, with a few notable differences. Children with morphea are more likely to present with the linear subtype and have a higher incidence of extracutaneous manifestations. Children often need early aggressive systemic treatment to try to prevent long-term sequelae of morphea. In DM, adult disease has a clear association with malignancy that is not seen in children. Adults have a higher rate of pulmonary involvement and increased mortality, whereas calcinosis is more common in juvenile DM. DLE in adults is generally considered to have a low rate of progression from discoid lesions alone to systemic lupus erythematosus (SLE). DLE is less common in children, but several studies have suggested a higher rate of progression from DLE to SLE in children compared with adults. (C) 2016 Published by Elsevier Inc.
机译：Morphea，皮肌炎（DM）和盘状红斑狼疮（DLE）是可以在任何年龄出现的自身免疫性胶原血管疾病。在所有这三种疾病中，儿童和成人的诊断和治疗承租人基本相同，但有一些显着差异。患有吗啡的儿童更容易出现线性亚型，并且皮外表现的发生率更高。儿童经常需要早期积极的全身治疗，以试图防止长期的吗啡后遗症。在DM中，成人疾病与恶性肿瘤有明显的联系，而儿童则没有。成人的肺受累率更高，死亡率更高，而钙化病在青少年DM中更为常见。通常认为成人DLE从盘状病变到全身性红斑狼疮（SLE）的进展率较低。 DLE在儿童中较少见，但几项研究表明，与成人相比，儿童从DLE到SLE的进展率更高。 （C）2016由Elsevier Inc.发布

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