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首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Dynamic model of hormonal systems coupled by negative feedback
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Dynamic model of hormonal systems coupled by negative feedback

机译：荷尔蒙系统动力学模型的负反馈耦合

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摘要

Most hormone concentrations in the body are regulated by negative feedback mechanisms in which the production and release of hormones are regulated according to the concentration of related species. Also, it has been observed that several hormones are released in a variety of pulsatile patterns. In most cases, the mechanism driving these complex patterns is not well understood. Our model of two cells coupled through negative feedback to their external products demonstrates periodic, aperiodic and chaotic oscillations. The coupling between the cells seems to be responsible for these dynamic behaviors. The variety of dynamic behaviors observed in the model demonstrates that a simple physiological feedback loop mimicking the coupling between circulatory hormones and production centers could be the source of complex hormone release patterns observed in vivo. (C) 1998 Elsevier Science B.V. All rights reserved. [References: 27]
机译：体内大多数激素的浓度是通过负反馈机制调节的，该机制根据相关物种的浓度调节激素的产生和释放。另外，已经观察到几种激素以各种搏动方式释放。在大多数情况下，对驱动这些复杂模式的机制了解得很少。我们通过负反馈耦合到其外部乘积的两个单元的模型演示了周期性，非周期性和混沌振荡。单元之间的耦合似乎负责这些动态行为。在模型中观察到的各种动态行为表明，模仿循环激素与生产中心之间耦合的简单生理反馈回路可能是体内观察到的复杂激素释放模式的来源。 （C）1998 Elsevier Science B.V.保留所有权利。 [参考：27]

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