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首页> 外文期刊>Journal of pharmacology & toxicology. >Protective Effect of N-acetyl Cysteine and/or Pro Vitamin A against Monosodium Glutamate-Induced Cardiopathy in Rats
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Protective Effect of N-acetyl Cysteine and/or Pro Vitamin A against Monosodium Glutamate-Induced Cardiopathy in Rats

机译：N-乙酰半胱氨酸和/或前维生素A对味精对大鼠心肌的保护作用

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摘要

In the present study the prophylactic effects of the antioxidants, p-carotene and/or N-acetyl cysteine (NAC) in ameliorating the metabolic abnormalities and oxidative damage induced cardiopathy under the effect of the flavor enhancers, monosodium glutamate (MSG) toxicity were studied. Animals were divided into 5 groups; Gl: normal control, G2: MSG-treated group, Gs 3,4 and 5: animals pretreated with either NAC or P-carotene or their combination prior MSG administration, respectively. The present results revealed that, chronic administration of MSG caused metabolic dysfunction characterized by significant increases in the levels of serum glucose, total lipids, triglycerides (TG), total cholesterol (TCh) and Low Density Lipoprotein (LDL) and a decrease in the high density lipoprotein (HDL), parameters have important role in MSG induced cardiovascular disorders. The adverse effects of MSG may be related to an imbalance between the oxidant and antioxidant systems.
机译：在本研究中，研究了抗氧化剂，对-胡萝卜素和/或N-乙酰半胱氨酸（NAC）在改善风味增强剂，谷氨酸钠（MSG）毒性作用下改善代谢异常和氧化损伤所致心脏病的预防作用。 。将动物分为5组。 G1：正常对照，G2：MSG治疗组，Gs 3，4和5：分别在施用MSG之前用NAC或β-胡萝卜素或它们的组合预处理的动物。目前的结果表明，长期服用味精会导致代谢功能异常，其特征在于血清葡萄糖，总脂质，甘油三酸酯（TG），总胆固醇（TCh）和低密度脂蛋白（LDL）的水平显着增加，而高胆固醇的降低密度脂蛋白（HDL），参数在味精诱发的心血管疾病中具有重要作用。 MSG的不利影响可能与氧化剂和抗氧化剂系统之间的不平衡有关。

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