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首页> 外文期刊>Journal of pharmacology & toxicology. >Hepatoprotective Activity of Coccinia grandis Leaves Against Carbon Tetrachloride Induced Hepatic Injury in Rats
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Hepatoprotective Activity of Coccinia grandis Leaves Against Carbon Tetrachloride Induced Hepatic Injury in Rats

机译：巨球藻叶片对四氯化碳所致大鼠肝损伤的保护作用

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摘要

Coccinia grandis Linn. (Cucurbitaceae) is a perennial branched handsome tendril climber, distributed through out India. It has been used in folk medicine for the treatment of jaundice. The aim of this work was to study the hepatoprotective effect of crude ethanolic and aqueous extracts from the leaves of C. grandis against liver damage induced by CC1_4 in rats. The ethanolic extract at an oral dose of 200 mg kg~-1 exhibited a significant (p<0.05) protective effect as shown by lowering serum levels of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase, total bilirubin and total cholesterol and increasing levels of total protein and albumin levels as compared to silymarin, the positive control. These biochemical observations were supported by histopathological examination of liver sections.
机译：大洋西兰花（葫芦科）是常年分支的英俊卷须登山者，分布在印度各地。它已在民间医学中用于治疗黄疸。这项工作的目的是研究大棒梭叶的粗乙醇提取物和水提取物对大鼠CC1_4诱导的肝损伤的肝保护作用。口服剂量为200 mg kg〜-1的乙醇提取物具有显着（p <0.05）的保护作用，如降低血清谷氨酸草酰乙酸转氨酶，谷氨酸丙酮酸转氨酶，碱性磷酸酶，总胆红素和总胆固醇水平并升高水平所示与阳性对照水飞蓟素的总蛋白和白蛋白水平相比这些生化观察得到肝脏切片的组织病理学检查的支持。

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