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首页> 外文期刊>Journal of pharmacology & toxicology. >Anticancer and Biochemical Effects of Calcium Chloride on Ehrlich Carcinoma Cell-Bearing Swiss Albino Mice
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Anticancer and Biochemical Effects of Calcium Chloride on Ehrlich Carcinoma Cell-Bearing Swiss Albino Mice

机译：氯化钙对埃氏癌细胞株瑞士白化小鼠的抗癌和生化作用

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摘要

The anticancer activity of calcium chloride was evaluated from the total count and viability of Ehrlich Ascites Carcinoma (EAC) cells and their proteins, nucleic acid, malondialdehyde (MDA) and Nonprotein sulfhydryl (NP-SH) groups in addition to observations on survival and the body weight changes. The tumors at site of injection were investigated for histopathological changes. The treatment with calcium chloride (50,100 and 200 mg/kg/day) caused cytotoxic activity. These data are substantiated by biochemical and histopathological changes and are attributed to calcium ions, which are known to disrupt calcium homeostasis, produce ROS, damage mitochondria and cause DNA breaks.
机译：除了观察存活率和存活率外，还从埃氏腹水癌（EAC）细胞及其蛋白质，核酸，丙二醛（MDA）和非蛋白质巯基（NP-SH）基团的总数和生存力评估氯化钙的抗癌活性。体重变化。研究注射部位的肿瘤的组织病理学变化。氯化钙（50,100和200 mg / kg /天）处理引起细胞毒性。这些数据通过生化和组织病理学改变得到证实，并归因于钙离子，已知该离子可破坏钙稳态，产生ROS，破坏线粒体并引起DNA断裂。

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