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首页> 外文期刊>Journal of pharmacology & toxicology. >Evaluation of Safety of Naturaliv~(TM) Liquid and Zist~R Liquid on Acute Oral Exposure in Rats
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Evaluation of Safety of Naturaliv~(TM) Liquid and Zist~R Liquid on Acute Oral Exposure in Rats

机译：Naturaliv〜（TM）液体和Zist〜R液体对大鼠急性口腔暴露的安全性评估

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Abstract: The objective of the current study was to assess the acute oral toxicity of some herbal veterinary preparations in female albino Wistar rats as per the OECD guidelines for testing of chemicals. Acute oral toxicity-Fixed dose procedure (Test guideline 420). The investigational substances, Naturaliv~(TM) Uquid and Zist~R liquid are used in poultiy for hepatoprotective and antioxidant properties, respectively. Naturaliv~(TM) liquid was tested at 5000 mg kg~(-1) b.wt., whereas Zist~R liquid was evaluated in sequential manner to one animal each at 2000 and 5000 mg kg~(-1) b.wt. in the sighting study, followed by four animals at 5000 mg kg~(-1) b.wt. in the main study. The treated animals were observed for mortality (twice daily), adverse clinical signs (once daily), changes in weekly body weight gain and gross necropsy findings. All the treated animals survived throughout the study period. Treatment with Naturaliv~(TM) liquid did not reveal any abnormal clinical signs at the tested dose level while Zist~R liquid treated rats exhibited few clinical signs for a transient period on the day of dosing. The overall percent body weight gain in rats was found to be normal during the 14 day observation period. The terminal sacrifice revealed no gross pathological lesions that can be attributable to treatment. Based on this, it can be stated that Naturaliv~(TM) liquid and Zist~R liquid, on single oral administration to female Wistar rats, were found to be safe up to 5000 mg kg~(-1) b.wt.
机译：摘要：本研究的目的是根据OECD化学品测试指南，评估某些草药兽医制剂对雌性白化Wistar大鼠的急性口服毒性。急性口服毒性固定剂量程序（测试指南420）。用于研究的物质Naturaliv_TM Uquid和Zist_R液体分别用于肝保护和抗氧化特性。以5000 mg kg〜（-1）b.wt.测试了NaturalivTM液体，而以每只动物的顺序对Zist_R液体进行了评估，分别为2000和5000 mg kg〜（-1）b.wt. 。在目击研究中，随后有四只动物以5000 mg kg〜（-1）b.wt.在主要研究中。观察治疗动物的死亡率（每天两次），不良临床体征（每天一次），每周体重增加的变化和尸检结果。在整个研究期间，所有处理过的动物均存活。在测试的剂量水平上，使用NaturalivTM液体治疗未显示任何异常的临床体征，而Zist_R液体治疗的大鼠在给药当天的短暂时间内几乎没有临床体征。在14天的观察期内，发现大鼠的总体体重增加百分比是正常的。最终的牺牲显示没有可归因于治疗的严重病理损伤。基于此，可以说，对雌性Wistar大鼠单次口服给药时，发现Naturaliv TM液体和Zist R液体是安全的，至多5000 mg kg·（-1）b.wt。

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