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首页> 外文期刊>Journal of pharmacology & toxicology. >Antifertility Activity of Hexane and Ethyl Acetate Extracts of Aerial Parts of Tragia involucrata. Linn
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Antifertility Activity of Hexane and Ethyl Acetate Extracts of Aerial Parts of Tragia involucrata. Linn

机译：苦茶地上部分正己烷和乙酸乙酯提取物的抗生育活性。林恩

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摘要

Many people in rural Bangladesh use a traditional contraceptive pill, "Shanti Bori" to control fertility in which Tragia involucrata is one of the components. The aim of the present study was to evaluate the validity of antifertility effect of this plant. The hexane (HE) and ethyl acetate extracts (EAE) of the aerial parts of T. involucrata have been evaluated for the anti-fertility activity in proven fertile female rats at dose of 200 mg kg"1 body weight. Preliminary phytochemical analysis showed the presence of phytosterols, triterpenes and flavonoids in the extracts. HE and EAE showed significant anti-fertility activity. It was found that the extracts reduced the number of litters born significantly at the dose of 200 mg kg"1 body weight. HE and EAE exhibited 81 and 50% antiimplantation potency respectively at the tested dose. The extracts also showed the estrogenic activity and potentiated the action of the standard drug ethanyl estradiol. All these observations suggest that extracts have antiimplantation as well as the abortifacient activity and are safe at the effective antifertility doses employed in this study.
机译：孟加拉国农村地区的许多人使用传统的避孕药“ Shanti Bori”来控制生育，其中Tragia involucrata是其中的成分之一。本研究的目的是评估该植物抗生育作用的有效性。业已证明，经证实的可育雌性大鼠在200 mg kg“ 1体重的剂量下，可对菊苣（T. involucrata）地上部分的己烷（HE）和乙酸乙酯提取物（EAE）进行抗生育活性的研究。初步植物化学分析表明，提取物中存在植物甾醇，三萜烯和类黄酮，HE和EAE具有明显的抗生育活性，发现在200 mg kg•1体重的剂量下，提取物可显着减少产仔数。在测试剂量下，HE和EAE分别显示出81％和50％的抗植入效力。提取物还显示出雌激素活性，并增强了标准药物乙炔雌二醇的作用。所有这些观察结果表明，提取物具有抗着床以及流产的活性，并且在本研究中使用的有效抗生育剂量下是安全的。

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