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首页> 外文期刊>Journal of pharmacology & toxicology. >Establishing the Principle of Herbal Therapy for Antiurolithiatic Activity: A Review
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Establishing the Principle of Herbal Therapy for Antiurolithiatic Activity: A Review

机译：建立抗尿石症活动的草药治疗原理：综述。

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A wide range of plants and plant-derived products are used in folk medicine for the treatment of urolithiasis as a prophylactic agent or as curative agent. Most of them found to be effective, but still the complete mechanism of action of these herbal drugs remains to be unclear. In present review we are discussing the various mechanism of action through which phytotheraeupatic agents exert their antiurolithiatic effect. Unlike allopathic medicines which targets only one aspect of urolithiatic pathophysiology, most of plant based therapy have been shown to be effective at different stages of stone pathophysiology. Currently known herbal drugs exert their antilithogenic properties by altering the ionic composition of urine viz.; decreasing the calcium and oxalate ion concentration or increasing magnesium and citrate excretion. Most of these remedies also express diuretic activity or lithotriptic activity. Some of the herbal drugs reported to disaggregate of mucoproteins, which are actually binds the crystal to the renal cells. Some medicinal plants contain chemical compounds like Glycosaminoglycans (GAGs) which themselves possess an inhibitory effect in the crystallization of calcium oxalate. Antioxidant constituents of the plants also help in ameliorating the crystal/oxalate induced renal cell injury. Thus, antiurolithiatic activity of plants or herbal formulation may be due to synergism of their diuretic activity, crystallization inhibition along with antioxidant activity.
机译：在民间医学中，用于预防尿石症的多种植物和植物来源的产品用作预防剂或治疗剂。他们中的大多数被发现是有效的，但是仍然不清楚这些草药的完整作用机理。在目前的审查中，我们正在讨论植物治疗药物通过其发挥抗尿石症作用的各种作用机制。与仅针对尿石症病理生理学的一个方面的同种疗法药物不同，大多数基于植物的疗法已被证明在结石病理生理学的不同阶段有效。当前已知的草药通过改变尿液的离子组成来发挥其抗石蜡作用。降低钙和草酸根离子的浓度或增加镁和柠檬酸的排泄。这些疗法中的大多数也表现出利尿活性或碎石活性。据报道，某些草药会分解粘蛋白，而粘蛋白实际上是将晶体与肾细胞结合在一起。一些药用植物含有诸如糖胺聚糖（GAG）的化合物，它们本身对草酸钙的结晶具有抑制作用。植物的抗氧化剂成分也有助于减轻晶体/草酸盐诱导的肾细胞损伤。因此，植物或草药制剂的抗尿石症活性可能是由于其利尿活性，结晶抑制以及抗氧化剂活性的协同作用。

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