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首页> 外文期刊>Journal of pharmacology & toxicology. >Potential Amelioration of Curcumin Against Nicotine-induced Toxicity of Protein Malnourished Female Rats
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Potential Amelioration of Curcumin Against Nicotine-induced Toxicity of Protein Malnourished Female Rats

机译：姜黄素对尼古丁引起的蛋白质营养不良雌性大鼠毒性的潜在改善作用

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摘要

Nicotine plays an important role on reproductive disorders, cardio-vascular diseases, different cancers and destruction of defence system in human. Its effect in protein malnourished condition is very little understood. This investigation was designed to determine the nicotine-induced toxicity (subcutaneously injected at a dose of 2.5 mg kg"1 b. wt. day"1 for 21 days) on different tissues of female albino rats and corresponding ameliorative observations of curcumin (orally supplemented at a dose of 80 mg kg"1 b. wt. day"1 during the treatment) under protein malnourished condition. Nicotine causes more significant (p<0.001) increase of glucose level, depletion protein and alteration of triglycerides and cholesterol levels in serum. Disruption of liver function and alteration of phosphatase enzymes are more significantly (p<0.001) occurred in protein restricted condition due to nicotine treatment. Nicotine also decreases the activity of antioxidant enzymes, increases lipid peroxidation and affects the production of female hormones more significantly (p<0.001) in such condition. Nicotine disrupts the structural integrity of ovary and uterus that may hamper normal pregnancy. Curcumin effectively ameliorates the deleterious effects of nicotine in protein malnourished condition and may be used in the diet as potential blocker of nicotine to protect the health of malnourished female population.
机译：尼古丁对生殖系统疾病，心血管疾病，各种癌症和防御系统的破坏起着重要作用。人们对蛋白质营养不良状况的影响了解甚少。该研究旨在确定尼古丁诱导的对雌性白化病大鼠不同组织的毒性（皮下注射，剂量为2.5 mg kg“ 1 b。wt。day” 1，连续21天），以及姜黄素的相应改善症状（口服补充）在蛋白质营养不良的条件下，以80mg / kg的剂量“在治疗期间1b.wt.day” 1给药。尼古丁会导致血清葡萄糖水平，消耗蛋白的增加以及血清甘油三酸酯和胆固醇水平的改变更为显着（p <0.001）。由于尼古丁治疗，在蛋白质受限的情况下，肝功能的破坏和磷酸酶的改变更为显着（p <0.001）。在这种情况下，尼古丁还降低了抗氧化酶的活性，增加了脂质过氧化作用，并更显着地影响女性激素的产生（p <0.001）。尼古丁破坏卵巢和子宫的结构完整性，可能会妨碍正常怀孕。姜黄素可有效改善蛋白质营养不良条件下尼古丁的有害作用，可在饮食中用作尼古丁的潜在阻断剂，以保护营养不良的女性人群的健康。

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