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首页> 外文期刊>Journal of pharmacology & toxicology. >Disposition Kinetic of Levofloxacin in Experimentally Induced Febrile Model of Sheep
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Disposition Kinetic of Levofloxacin in Experimentally Induced Febrile Model of Sheep

机译：实验性羊热性模型中左氧氟沙星的处置动力学

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摘要

The present study was planned to investigate pharmacokinetics of levofloxacin following a single dose (3 mg kg(-1)) intravenous (i.v.) and subcutaneous (s.c.) administration in sheep with febrile condition. Plasma samples were collected after each treatment in crossover design and analyzed for drug concentration using High Performance Liquid Chromatography (HPLC). Following intravenous administration, the drug was rapidly and widely distributed in the body with distribution and elimination half-lives of 0.24+-0.03 and 2.15+-0.07 h, respectively. The high volume of distribution of the drug with total clearance of 0.42+-0.03 L h~(-1) kg(-1) was observed. The drug was rapidly absorbed from subcutaneous site of administration and maximum drug concentration (C_(max)) of 1.60+-0.09 mug muL(-1) was achieved at 1 h (T_(max)). The elimination half-life and total body clearance of the drug was comparative to those observed following intravenous injection. The bioavailability (F) of the drug following subcutaneous administration in febrile sheep was 89.20+-3.84%. Pharm acokinetic characteristics and absence of adverse reactions in the present study revealed that levofloxacin may be a potentially useful drug to treat bacterial diseases in sheep having acute phase reaction.
机译：本研究计划研究在发热的绵羊中单次（3 mg kg（-1））静脉内（i.v.）和皮下（s.c.）给药后左氧氟沙星的药代动力学。在交叉设计中的每次处理后收集血浆样品，并使用高效液相色谱（HPLC）分析药物浓度。静脉内给药后，该药物在体内迅速广泛分布，分布和消除半衰期分别为0.24 + -0.03和2.15 + -0.07 h。观察到药物的高分布体积，总清除率为0.42 + -0.03 L h〜（-1）kg（-1）。药物从皮下给药部位迅速吸收，并在1小时内达到1.60 + -0.09杯muL（-1）的最大药物浓度（C_（max））（T_（max））。该药物的消除半衰期和总体清除率与静脉注射后观察到的相当。在高热绵羊皮下给药后，该药物的生物利用度（F）为89.20 + -3.84％。在本研究中，药物的药动学特征和无不良反应表明左氧氟沙星可能是治疗患有急性期反应的绵羊细菌性疾病的潜在有用药物。

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