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首页> 外文期刊>Journal of pharmacology & toxicology. >Haemato-biochemical Effects of Formulated and Technical Cypermethrin and Deltamethrin Insecticides in Male Rats
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Haemato-biochemical Effects of Formulated and Technical Cypermethrin and Deltamethrin Insecticides in Male Rats

机译：配方和技术氯氰菊酯和溴氰菊酯杀虫剂对雄性大鼠的血液生化作用

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摘要

Pesticide formulations are complex mixtures and the toxicity information on active ingredients alone is not sufficient to evaluate the risk of adverse health effects of commercial pesticides. So, the present work was conducted to study the haemato-biochemical effects of technical and formulated cypermethrin (25.0 mg kg~(-1) b.wt.) and deltamethrin (1.70 mg kg~(-1) b.wt.), in male rats given repetitive oral doses for 90 consecutive days. There was high significant decrease (p<=0.01) in body weight gain of cypermethrin and significant decrease (p<=0.05) in deltamethrin treated rats. The relative liver and kidney weights were significantly change in the treatments of formulated and technical cypermethrin and deltamethrin compared to the control. Deltamethrin as technical or formulated form caused significant changes (p<=0.01) in haemoglobin, packed cell value and Red Blood Cell (RBC), while formulated and technical cypermethrin caused significant decrease (p<=0.05) in PCV % and formulated cypermethrin induced significant decrease (p<=0.01) in White Blood Cell (WBC) compared to control value. Treatments with formulated and technical cypermethrin and deltamethrin caused significant increase (p<=0.01) in serum Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) activities and formulated cypermethrin seemed to induce higher AST elevation (200.67 IU L~(-1)) and formulated deltamethrin induce higher ALT elevation (105.07 IU L~(-1)) as compared with the untreated group (21.30 and 25.50 IU L~(-1) respectively). Technical cypermethrin and deltamethrin caused highly significant (p<=0.01) decreased in serum glucose. On the other hand all of the tested insecticides induced significant decreases (p<=0.05) in serum total protein and increase (p<=0.05-0.01) in creatinine and uric acid concentrations. The partial differences of hematological and biochemical effects obtained with pure and commercial deltamethrin and cypermethrin indicate that commercial formulations may contain additional hazardous compounds. Therefore, it is important in assessing the real human hazard from pesticides to investigate not only the active principle but also the commercial formulations used in agriculture.
机译：农药制剂是复杂的混合物，仅活性成分的毒性信息不足以评估商业农药对健康造成不利影响的风险。因此，目前的工作是为了研究技术和配制的氯氰菊酯（25.0 mg kg〜（-1）b.wt.）和溴氰菊酯（1.70 mg kg〜（-1）b.wt.）的血液生化作用，在雄性大鼠中连续90天重复口服。氯氰菊酯的体重增加具有高度显着的降低（p <= 0.01），而溴氰菊酯处理的大鼠具有显着的降低（p <= 0.05）。与对照相比，在配方和工业氯氰菊酯和溴氰菊酯的治疗中，相对肝脏和肾脏的重量发生了显着变化。溴氰菊酯作为技术或制剂形式引起的血红蛋白，堆积细胞值和红细胞（RBC）发生显着变化（p <= 0.01），而制剂和技术上的氯氰菊酯引起的PCV％显着降低（p <= 0.05），而所配制的氯氰菊酯引起与对照值相比，白细胞（WBC）显着降低（p <= 0.01）。配方氯氰菊酯和技术性氯氰菊酯和溴氰菊酯的处理导致血清天冬氨酸转氨酶（AST）和丙氨酸氨基转移酶（ALT）活性显着增加（p <= 0.01），配制的氯氰菊酯似乎诱导更高的AST升高（200.67 IU L〜（-1））与未治疗组（分别为21.30和25.50 IU L〜（-1））相比，加用溴氰菊酯和处方溴氰菊酯的ALT升高更高（105.07 IU L〜（-1））。工业氯氰菊酯和溴氰菊酯引起的血清葡萄糖下降极显着（p <= 0.01）。另一方面，所有测试的杀虫剂均引起血清总蛋白的显着降低（p <= 0.05）和肌酐和尿酸浓度的升高（p <= 0.05-0.01）。用纯和商用溴氰菊酯和氯氰菊酯获得的血液和生化作用的部分差异表明，商用制剂可能含有其他有害化合物。因此，重要的是评估农药的实际人为危害，不仅要研究活性成分，而且要研究农业中使用的商业配方。

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