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首页> 外文期刊>Journal of pharmacology & toxicology. >Effects of Methanol Extract of Buchholzia coriacea Fruit in Streptozotocin-induced Diabetic Rats
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Effects of Methanol Extract of Buchholzia coriacea Fruit in Streptozotocin-induced Diabetic Rats

机译：啤酒花果实甲醇提取物对链脲佐菌素诱导的糖尿病大鼠的作用

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摘要

The hypoglycemic and anti-oxidant effects of the methanolic extract of Buchholzia coriacea fruits in streptozotocin-induced diabetic rats were investigated. It was tolerated up to dose of 2000 mg kg"1 orally in rats. Treatment with 150, 300 and 600 mg kg"1 of the extract induced significant (p<0.05) dose dependent decreases in the respective fasting blood glucose values of 6.61+2.14, 5.12+1.01 and 3.84+0.81 mmol L"1 from the initial mean value of 14.15±5.12 mmol Lr1 when compared with the negative control. Glibenclamide (2 mg kg"1) however, lowered the fasting blood glucose to 3.51±0.75 mmol Lr1. The serum concentrations of catalase and reduced glutathione were significantly (p<0.05) higher in rats treated with glibenclamide (2 mg kg"1) and various doses (150, 300 and 600 mg kg"1) of the extract in contrast to the values in negative control rats. The extract also decreased serum triglycerides and total serum cholesterol. The fruit extract dose dependently reduced lipid peroxidation in diabetic rats. The ability of scavenging free radicals was measured by DPPH reduction and Ferric Reducing/Antioxidant Power (FRAP) spectrophotometric assays. In the DPPH assay, the highest concentration (400 jig mL"1) of the extract produced 66% antioxidant activity compared to 80% with ascorbic acid at the same concentration. The FRAP value increased concentration dependently from 1.1 to 1.7 jiM (100-400 (j,g mL"1). while ascorbic acid has a FRAP value of 2 ^M at 1000 (xg mL"1. The findings suggest that the extract could be a potential source of a novel anti-diabetic and antioxidant agent.
机译：研究了链节藻果实的甲醇提取物在链脲佐菌素诱导的糖尿病大鼠中的降血糖和抗氧化作用。在大鼠中口服剂量最高可达200​​0 mg kg“ 1。用150、300和600 mg kg” 1的提取物处理后，相应的空腹血糖值显着（p <0.05）降低了6.61+与阴性对照相比，初始平均值分别为14.15±5.12 mmol Lr1 2.14、5.12 + 1.01和3.84 + 0.81 mmol L“ 1。然而，格列本脲（2 mg kg” 1）将空腹血糖降至3.51±0.75毫摩尔Lr1。与格列本脲（2 mg kg“ 1）和各种剂量（150、300和600 mg kg” 1）提取物处理的大鼠相比，过氧化氢酶和还原型谷胱甘肽的血清浓度显着（p <0.05）高在阴性对照大鼠中。提取物还降低了血清甘油三酸酯和总血清胆固醇。水果提取物剂量依赖性地降低糖尿病大鼠的脂质过氧化。通过DPPH还原和铁还原/抗氧化能力（FRAP）分光光度法测定清除自由基的能力。在DPPH分析中，最高浓度的提取物（400夹具mL“ 1）具有66％的抗氧化活性，而相同浓度的抗坏血酸具有80％的抗氧化活性。FRAP值将浓度从1.1 jiM增加到1.7 jiM（100-400 （j，g mL“ 1）。而抗坏血酸在1000（xg mL” 1时的FRAP值为2 ^ M。研究结果表明，该提取物可能是新型抗糖尿病和抗氧化剂的潜在来源。

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