Improvement of postischemic dopaminergic dysfunction by edaravone, a free radical scavenger.

Akiyama Y; Miwa S

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Improvement of postischemic dopaminergic dysfunction by edaravone, a free radical scavenger.

机译：依达拉奉（一种自由基清除剂）改善缺血性多巴胺能功能障碍。

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Effects of a free radical scavenger, edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), on ischemia/reperfusion-induced dysfunctions of rat striatal dopaminergic neurons were examined using in vivo brain microdialysis. During transient forebrain ischemia, dopamine levels in dialysates were elevated 140-fold above controls but rapidly recovered after reperfusion. The increase in dopamine levels induced by high K+ stimulation after reperfusion was far smaller than that of the controls. Pretreatment with edaravone but not post-treatment dose-dependently improved the response to high K+ but not the massive dopamine increase during ischemia. These results suggest that free radicals produced during ischemia play more important roles in ischemia/reperfusion-induced dysfunctions of dopaminergic neurons.

机译：使用体内脑微透析检查了自由基清除剂依达拉奉（3-甲基-1-苯基-2-吡唑啉-5-酮）对缺血/再灌注诱导的大鼠纹状体多巴胺能神经元功能障碍的影响。在短暂性前脑缺血期间，透析液中的多巴胺水平比对照升高了140倍，但在再灌注后迅速恢复。再灌注后高K +刺激引起的多巴胺水平的增加远小于对照组。依达拉奉预处理但不随剂量依赖性改善缺血时对高K +的反应，但对多巴胺的大量增加没有改善。这些结果表明，在缺血期间产生的自由基在缺血/再灌注诱导的多巴胺能神经元功能障碍中起着更重要的作用。

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《Journal of pharmacological sciences.》 |2007年第1期|共4页
作者
Akiyama Y; Miwa S;
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正文语种 eng
中图分类药理学;
关键词
Ischemia; edaravone; Physiological reperfusion; Free Radical Scavengers; 局部缺血; 自由基清除剂; 多巴胺;

机译：Ischemia;edaravone;Physiological reperfusion;Free Radical Scavengers;局部缺血;自由基清除剂;多巴胺;

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1. Improvement of postischemic dopaminergic dysfunction by edaravone, a free radical scavenger. [J] . Akiyama Y, Miwa S Journal of pharmacological sciences. . 2007,第1期

机译：依达拉奉（一种自由基清除剂）改善缺血性多巴胺能功能障碍。
2. Acute urinary retention and subsequent catheterization cause lipid peroxidation and oxidative DNA damage in the bladder: preventive effect of edaravone, a free-radical scavenger. [J] . Shimizu S, Saito M, Kinoshita Y BJU international . 2009,第5期

机译：急性尿retention留和随后的导管插入术会在膀胱中引起脂质过氧化和DNA氧化损伤：依达拉奉（一种自由基清除剂）的预防作用。
3. Temporal effects of edaravone, a free radical scavenger, on transient ischemia-induced neuronal dysfunction in the rat hippocampus. [J] . Otani H, Togashi H, Jesmin S, European Journal of Pharmacology: An International Journal . 2005,第2a3期

机译：依达拉奉（一种自由基清除剂）对大鼠海马短暂性缺血诱导的神经元功能障碍的时间影响。
4. The effects of a free radical scavenger, edaravone,combined with mild hypothermia on ischemic brain damage following transient middle cerebral artery occlusion in rats [C] . Chikako Nito, Tatsushi Kamiya, Shimon Amemiya, International Symposium on Molecular Mechanism and Epochal Therapeutics for Ischemic Stroke and Dementia . 2003

机译：自由基清除剂，依达拉夫酮与轻度体温过低的效果对大鼠瞬时中脑动脉闭塞后缺血性脑损伤
5. Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal: A mechanism of free radical mediated mitochondrial dysfunction. [D] . Humphries, Kenneth Michael. 2000

机译：4-羟基-2-壬烯醛抑制NADH连锁的线粒体呼吸：自由基介导的线粒体功能障碍的机制。
6. Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog. [O] . R Bolli, M O Jeroudi, B S Patel, 1989

机译：直接证据表明源自氧的自由基会导致完整犬的缺血后心肌功能障碍。
7. Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog. [O] . Bolli, R, Jeroudi, M O, Patel, B S, 1989

机译：直接证据表明，源自氧的自由基会导致完整犬的缺血后心肌功能障碍。

Improvement of postischemic dopaminergic dysfunction by edaravone, a free radical scavenger.

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