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首页> 外文期刊>Journal of pharmacological sciences. >Effects of serotonergic anxiolytics on the freezing behavior in the elevated open-platform test in mice.
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Effects of serotonergic anxiolytics on the freezing behavior in the elevated open-platform test in mice.

机译：在升高的开放平台试验中，血清素能抗焦虑药对冷冻行为的影响。

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Freezing behavior is thought to be a sign of fear in animals. We examined whether the freezing behavior during the elevated open-platform stress, which is a psychological stressor without painful stimulus, is modulated by serotonergic neurotransmission and would be a useful marker for screening anxiolytic and/or antidepressant. Male ICR mice (6 - 8-week-old) were individually placed on an elevated open-platform and the duration of freezing behavior of mouse was measured for 10 min. Fluoxetine and citalopram, selective serotonin (5-HT) reuptake inhibitors, markedly decreased the duration of freezing. Fenfluramine, a 5-HT releaser, and 8-OH-DPAT, a potent 5-HT1A-receptor agonist, also significantly decreased the duration of freezing. In contrast, the 5-HT-synthesis inhibitor p-chlorophenylalanine significantly increased the duration of freezing. Diazepam, a benzodiazepine anxiolytic, had no effect on the duration of freezing at doses having no effect on locomotor activity. Imipramine and clomipramine, tricyclic antidepressants, also did not affect the duration of freezing. Reboxetine, a selective noradrenaline reuptake inhibitor, significantly increased the duration of freezing. These results indicate that the activation of serotonergic neurotransmission attenuates the fear-related behavior in the elevated open-platform test, while the activation of noradrenergic neurotransmission increases the fear-related behavior. In addition, this test is convenient for assaying anxiolytic drugs that affect serotonergic neurotransmission.
机译：冻结行为被认为是动物恐惧的标志。我们检查了升高的开放平台压力（这是一种无痛苦刺激的心理压力源）期间的冰冻行为是否受到血清素能神经传递的调节，并且将成为筛选抗焦虑药和/或抗抑郁药的有用标志物。将雄性ICR小鼠（6-8周大）分别置于升高的开放平台上，并测量小鼠的冰冻行为持续时间10分钟。氟西汀和西酞普兰是选择性5-羟色胺（5-HT）再摄取抑制剂，可显着降低冷冻时间。 5-HT释放剂芬氟拉明和有效的5-HT1A受体激动剂8-OH-DPAT也显着降低了冷冻时间。相反，5-HT合成抑制剂对氯苯丙氨酸显着增加了冷冻时间。苯二氮卓类抗焦虑药地西p对冷冻时间没有影响，而剂量对运动活性没有影响。三环抗抑郁药丙咪嗪和氯丙咪嗪也不影响冷冻时间。选择性去甲肾上腺素再摄取抑制剂瑞波西汀显着增加了冷冻时间。这些结果表明，在升高的开放平台测试中，血清素能神经传递的激活减弱了恐惧相关行为，而去甲肾上腺素能神经传递的激活则增强了恐惧相关行为。另外，该测试方便用于测定影响血清素能神经传递的抗焦虑药。

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