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首页> 外文期刊>Journal of pharmacological sciences. >Circadian rhythms in the CNS and peripheral clock disorders: the circadian clock and hyperlipidemia.
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Circadian rhythms in the CNS and peripheral clock disorders: the circadian clock and hyperlipidemia.

机译：中枢神经系统和周围时钟紊乱的昼夜节律：昼夜节律和高脂血症。

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摘要

A circadian clock controls various physiological and behavioral rhythms. In mammals, a master circadian clock exists in the suprachiasmatic nucleus of the hypothalamus, and slave oscillators can be found in most tissues. These circadian oscillations are controlled by "clock genes". The negative feedback loop is thought to function as a molecular mechanism of the circadian clock. It is plausible that clock genes may control lipid metabolism through so-called clock-controlled genes and that lipid metabolism-related clock-controlled genes may play important roles in the circadian change of lipid metabolism. Recently research has focused on the relationships between the clock system and lipid metabolism. In this review, we discuss the following items: 1) circadian clock system, 2) effect of the diet on clock gene expression, 3) effect of clock mutation on lipid metabolism, and 4) effect of streptozotocin-induced diabetes and ob mutation on clock gene expression and lipid metabolism. In this review we have summarized how the circadian clock affects lipid metabolism through the expression of lipid metabolism-related clock-controlled genes and at the same time discussed how abnormal metabolism of lipid affects the expression of clock genes. Further experiments are needed to elucidate the detailed mechanism of interaction between clock genes and lipid metabolisms.
机译：昼夜节律控制各种生理和行为节律。在哺乳动物中，下丘脑上眼睑上核存在一个昼夜节律的主钟，并且在大多数组织中都可以找到从动振荡器。这些昼夜节律振荡受“时钟基因”控制。负反馈回路被认为是生物钟的分子机制。可能的是，时钟基因可以通过所谓的时钟控制基因控制脂质代谢，而与脂质代谢相关的时钟控制基因可能在脂质代谢的昼夜变化中起重要作用。最近的研究集中在时钟系统和脂质代谢之间的关系。在这篇综述中，我们讨论以下项目：1）昼夜节律系统，2）饮食对时钟基因表达的影响，3）时钟突变对脂质代谢的影响，以及4）链脲佐菌素诱发的糖尿病和ob突变对糖尿病的影响时钟基因表达和脂质代谢。在这篇综述中，我们总结了昼夜节律如何通过脂质代谢相关的时钟控制基因的表达影响脂质代谢，同时讨论了脂质的异常代谢如何影响时钟基因的表达。需要进一步的实验来阐明时钟基因与脂质代谢之间相互作用的详细机制。

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