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首页> 外文期刊>Journal of pharmacological sciences. >Beta2-agonist clenbuterol induced changes in the distribution of white blood cells in rats.
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Beta2-agonist clenbuterol induced changes in the distribution of white blood cells in rats.

机译:Beta2-激动剂克仑特罗诱导大鼠白细胞分布变化。

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摘要

Clenbuterol [CLE: 4-amino-alpha(t-butyl-amino)methyl-3,5-dichlorobenzyl alcohol] is well known as a potent beta2-adrenergic agonist and non-steroidal anabolic drug, and thus it is generally used for sports doping and asthma therapy. Although the functions of immune cells such as white blood cells (WBCs) have shown to be modulated through beta2-adrenoceptors, the effects of CLE on immune-responsive systems have not been elucidated systematically. Therefore, the effects of CLE on the number of WBCs were studied in rats. Male adult rats were divided into CLE-administered group and the control group to compare the number of total WBCs, neutrophils, monocytes, lymphocytes, eosinophils, and basophils. The administration (dose = 1.0 mg . kg(-1) body weight . day(-1), s.c.) of CLE was maintained for 30 days. CLE did not change the number of total WBCs during the experimental period. However, CLE increased significantly the number of neutrophils and monocytes, while CLE decreased drastically the number of lymphocytes and eosinophils. There was no significant change in the number of basophils between both groups. These results suggest that the administration of CLE induces drastic redistribution of WBCs in circulation without changing the number of total WBCs, and these responses of WBCs during the administration of CLE are sustained for at least 30 days.
机译:瘦肉精[CLE:4-氨基-α-(叔丁基氨基)甲基-3,5-二氯苄醇]是一种有效的β2-肾上腺素能激动剂和非甾体合成代谢药物,因此通常用于运动兴奋剂和哮喘治疗。尽管已显示免疫细胞(例如白细胞(WBC))的功能通过beta2-肾上腺素能受体进行调节,但尚未系统地阐明CLE对免疫应答系统的作用。因此,在大鼠中研究了CLE对白细胞数量的影响。将雄性成年大鼠分为CLE给药组和对照组,以比较总白细胞,中性粒细胞,单核细胞,淋巴细胞,嗜酸性粒细胞和嗜碱性粒细胞的数量。 CLE的给药(剂量= 1.0 mg。kg(-1)体重。day(-1),皮下注射)维持30天。在试验期间,CLE并没有改变白细胞总数。但是,CLE显着增加了中性粒细胞和单核细胞的数量,而CLE则大大减少了淋巴细胞和嗜酸性粒细胞的数量。两组之间的嗜碱性粒细胞数量没有显着变化。这些结果表明,CLE的施用诱导了循环中WBC的急剧重新分布,而没有改变总WBC的数量,并且在CLE施用期间WBC的这些反应持续至少30天。

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