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首页> 外文期刊>Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland >Demonstration of insulin production and storage in insulinomas by in situ hybridization and immunocytochemistry.
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Demonstration of insulin production and storage in insulinomas by in situ hybridization and immunocytochemistry.

机译：通过原位杂交和免疫细胞化学证明胰岛素瘤中胰岛素的产生和储存。

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摘要

Twelve cases of insulinoma were studied to assess the amount of hormone synthesis and hormone storage by the tumour and to see what effect a hormone-producing tumour has on the adjacent normal islets. This was investigated by performing in situ hybridization, which detects hormone messenger RNA, thus giving an indication of the degree of hormone synthesis by the tumour, and immunocytochemistry, which detects the hormone itself, thus giving an indication of the amount of hormone stored in the tumour cells. It was found that in most cases there was less hormone stored within the tumour cells than in adjacent islet cells. In a minority of cases, this decrease in stored hormone was associated with reduced hormone synthesis, but the majority of cases showed either equivalent or increased levels of hormone mRNA in the tumour cells compared with adjacent islets. In addition, it was noted that, unlike some other endocrine organs, the presence of a hormone-producing tumour within the pancreas did not appear to inhibit hormone synthesis in the adjacent normal tissue.
机译：研究了十二例胰岛素瘤，以评估肿瘤的激素合成和激素储存量，并观察产生激素的肿瘤对相邻正常胰岛的影响。通过进行原位杂交（检测荷尔蒙信使RNA，从而指示肿瘤中激素合成的程度），以及进行免疫细胞化学（检测荷尔蒙自身，从而指示存储在激素中的激素量）来进行研究。肿瘤细胞。发现在大多数情况下，与相邻的胰岛细胞相比，肿瘤细胞内存储的激素较少。在少数情况下，这种储存激素的减少与激素合成的减少有关，但大多数情况下，与邻近的胰岛相比，肿瘤细胞中激素mRNA的水平相等或升高。另外，应注意的是，与某些其他内分泌器官不同，胰腺内产生激素的肿瘤的出现似乎并未抑制邻近正常组织中的激素合成。

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