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首页> 外文期刊>Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland >Variation of bcl-2 expression in breast ducts and lobules in relation to plasma progesterone levels: overexpression and absence of variation in fibroadenomas.
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Variation of bcl-2 expression in breast ducts and lobules in relation to plasma progesterone levels: overexpression and absence of variation in fibroadenomas.

机译：乳腺导管和小叶中bcl-2表达的变化与血浆孕酮水平的关系：纤维腺瘤的过度表达和变化。

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Some women with benign breast disease eventually develop breast cancer. The mammary gland undergoes tissue remodelling according to hormonal influences, involving a balance between quiescence, proliferation, and mechanisms of cell death. Proliferation and/or apoptotic events could therefore be investigated to help understand the mechanisms of benign lesion formation and identify mastopathies with a poor prognosis. bcl-2 expression was analysed by immunohistochemistry in 75 benign mastopathies. Protein levels were quantitated with an image analyser in various epithelial structures on frozen sections, including adenoses, fibroadenomas, ductal epithelial hyperplasias, cysts, and apparently normal surrounding lobules and ducts. bcl-2 levels were equivalent in apparently normal lobules and ducts, as well as in cysts and ductal hyperplasias. bcl-2 staining was significantly higher in fibroadenomas, known to be of lobular origin [mean = 10.1, quantitative immunochemistry score (QIC) arbitrary units (AU), n = 19], than in normal lobules (mean = 5.1 AU, n = 43, P = 7 x 10(-5). bcl-2 levels in normal lobules and ducts varied according to the menstrual cycle, being higher during the follicular than the luteal phase (P = 1.8 x 10(-2) and P = 1.7 x 10(-2), respectively). This was further supported by a statistical link (P = 5 x 10(-3) between high levels of circulating progesterone and weak bcl-2 staining in lobules and ducts. This progesterone-dependent variation was absent in fibroadenomas. No statistical correlation was found between bcl-2 expression and circulating levels of oestradiol, and follicle-stimulating or luteotrophic hormones. Although these are only preliminary results, they suggest an influence of progesterone on bcl-2 expression which might be lost in fibroadenomas. A hypothesis is proposed concerning the potential involvement of altered regulation of the apoptotic process in the formation of such benign lesions.
机译：一些患有良性乳腺疾病的妇女最终会患上乳腺癌。乳腺根据激素的影响进行组织重塑，涉及静止，增殖和细胞死亡机制之间的平衡。因此可以研究增殖和/或凋亡事件，以帮助了解良性病变的形成机制，并确定预后不良的乳腺病。通过免疫组织化学分析了75例良性乳腺病中bcl-2的表达。用图像分析仪在冰冻切片的各种上皮结构中定量蛋白质水平，包括腺体，纤维腺瘤，导管上皮增生，囊肿和显然正常的周围小叶和导管。在明显正常的小叶和导管，以及在囊肿和导管增生中，bcl-2水平是相等的。已知是小叶起源的纤维腺瘤中bcl-2染色明显高于正常小叶（平均值= 5.1 AU，n = 19，平均值为10.1，定量免疫化学评分（QIC）任意单位（AU），n = 19）。 43，P = 7 x 10（-5）。正常小叶和导管中bcl-2的水平根据月经周期而变化，在卵泡期高于黄体期（P = 1.8 x 10（-2），P =分别为1.7 x 10（-2））和统计学上的联系（P = 5 x 10（-3）在循环中的高水平孕激素水平与小叶和导管中弱bcl-2染色之间存在联系。纤维腺瘤中无变异; bcl-2表达与循环水平的雌二醇，促卵泡激素或黄体营养激素之间无统计学相关性，尽管这些只是初步结果，但它们提示黄体酮对bcl-2表达有影响。在纤维腺瘤中丢失。在这种良性病变的形成中涉及凋亡过程调节的改变。

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