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首页> 外文期刊>Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland >Evaluation of tumour angiogenesis as a prognostic marker in malignant mesothelioma.
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Evaluation of tumour angiogenesis as a prognostic marker in malignant mesothelioma.

机译：评估肿瘤血管生成作为恶性间皮瘤的预后指标。

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摘要

Angiogenesis plays an important role in the growth, progression, and metastasis of solid tumours. Malignant mesothelioma (MM) of the pleura is a highly invasive tumour with a poor prognosis. In the present study, microvascular quantification was undertaken on 25 specimens of mesothelioma and 15 specimens of non-neoplastic mesothelium (NNM), by staining for the antigens CD34 and CD31. Areas of highest intratumoural microvascular density (IMD) were identified and counted either manually (mIMD) or on a computerized image analysis system (CIAS; iIMD). The two IMDs were significantly correlated with each other (r = 0.736; P < 0.001). The average IMD for MM was significantly (P < 0.001) higher than in NNM. Moreover, each unit increment in iIMD for MM, when regarded as a continuous variable, was significantly (P = 0.001) associated with an increased hazard of about 4 per cent. When regarded as a categorical variable, the patients in the highest tertile (> 58 vessels/field) had a significantly (P < 0.01; log-rank test) shorter survival than patients in the lowest tertile (< 45 vessels/field). This association was independent of the age of the patient and of the histological type or grade of the MM. No association was noted with p53 immunoexpression. Although the mean vascular area of blood vessels measured on the CIAS did not correlate with survival, assessment of IMDs can be an important independent prognostic indicator in malignant mesothelioma.
机译：血管生成在实体瘤的生长，进展和转移中起重要作用。胸膜恶性间皮瘤（MM）是一种高浸润性肿瘤，预后较差。在本研究中，通过对抗原CD34和CD31染色，对25个间皮瘤标本和15个非肿瘤性间皮瘤（NNM）标本进行了微血管定量。手动（mIMD）或计算机图像分析系统（CIAS; iIMD）识别并计数肿瘤内微血管密度（IMD）最高的区域。两种IMD之间存在显着相关性（r = 0.736; P <0.001）。 MM的平均IMD明显高于NNM（P <0.001）。此外，MM的iIMD中每增加一个单位，当被认为是一个连续变量时，显着（P = 0.001）伴随着大约4％的危险增加。当视为分类变量时，三分位数最高（> 58血管/视野）的患者生存期显着（P <0.01;对数秩检验）比最低三分位数（<45血管/视野）的患者生存期短。这种关联与患者的年龄以及MM的组织学类型或等级无关。没有发现与p53免疫表达有关。尽管在CIAS上测得的平均血管面积与生存率无关，但对IMD的评估可能是恶性间皮瘤的重要独立预后指标。

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