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首页> 外文期刊>Journal of Pathology: Journal of the Pathological Society of Great Britain and Ireland >Correlations between p21 expression and clinicopathological findings, p53 gene and protein alterations, and survival in patients with endometrial carcinoma.
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Correlations between p21 expression and clinicopathological findings, p53 gene and protein alterations, and survival in patients with endometrial carcinoma.

机译：子宫内膜癌患者中p21表达与临床病理结果，p53基因和蛋白质改变以及生存率之间的相关性。

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The p21 protein inhibits cyclin-dependent kinases and mediates cell-cycle arrest and cell differentiation. It is induced by wild-type p53, but not by mutant p53. This study of 75 patients with endometrial carcinoma investigates the relationship between p21 expression and the functional status of p53, and the usefulness of p21 as a prognostic marker. Correlations were determined between p21 immunoreactivity, p53 overexpression as examined by immunohistochemistry, p53 DNA mutations as examined by polymerase chain reaction-single-stranded conformation polymorphism (PCR-SSCP) analysis, and clinicopathological features, including the clinical outcome. Immunoreactivity for p21 and p53 mutations were detected in 47 (62.7 per cent), 37 (49 per cent), and 23 (31 per cent) patients, respectively. There were no significant correlations between the presence or absence of p21 immunoreactivity and p53 overexpression and DNA mutations. Survival curves revealed that patients with p53 overexpression tended to have a poorer prognosis than those without p53 overexpression (P = 0.104), that patients with p53 mutations had a significantly worse prognosis than those without mutations (P = 0.035), and that patients with p21 expression tended to have a better prognosis than those without p21 expression (P = 0.074). Immunohistochemical analysis of p21 was not useful for evaluating the functional status of p53 in patients with endometrial carcinoma. Both p21 expression and p53 abnormalities were considered as prognostic indicators in patients with endometrioid endometrial carcinoma.
机译：p21蛋白抑制细胞周期蛋白依赖性激酶并介导细胞周期停滞和细胞分化。它是由野生型p53诱导的，而不是由突变体p53诱导的。这项对75例子宫内膜癌患者的研究探讨了p21表达与p53功能状态之间的关系，以及p21作为预后指标的有用性。确定了p21免疫反应性，通过免疫组织化学检查的p53过表达，通过聚合酶链反应-单链构象多态性（PCR-SSCP）分析检查的p53 DNA突变与临床病理特征（包括临床结果）之间的相关性。 p21和p53突变的免疫反应性分别在47位（62.7％），37位（49％）和23位（31％）患者中检测到。 p21免疫反应性的存在与否与p53过表达和DNA突变之间无显着相关性。生存曲线显示，p53过度表达的患者的预后往往较无p53过度表达的患者（P = 0.104）更差，p53突变的患者的预后要比无突变的患者（P = 0.035）和p21的患者差得多与无p21表达的患者相比，p53表达的患者预后更好（P = 0.074）。 p21的免疫组织化学分析不能用于评估子宫内膜癌患者中p53的功能状态。 p21表达和p53异常均被认为是子宫内膜样子宫内膜癌患者的预后指标。

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