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Forecasting Influenza Epidemic based on Mutation Probability of HA/NA Protein

机译:基于HA / NA蛋白突变概率的流感流行预测

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摘要

The HA/NA protein sequences of the influenza virus from 1914 to 2012 are studied and the early-warning signal indicator values (the differences between predictable and unpredictable portions) for influenza pandemic outbreak are worked out through the calculation of the actual and predicted frequencies of amino-acid pairs. It is concluded that the differences between predictable and unpredictable portions for the pandemic years are significantly smaller than those for the adjacent years. Furthermore, it is also verified that the mutations of influenza virus HA/NA protein will cause influenza pandemic.
机译:研究了1914年至2012年流感病毒的HA / NA蛋白序列,并通过计算流感病毒大流行的实际和预测频率得出了流感大流行爆发的预警信号指标值(可预测部分与不可预测部分之间的差异)。氨基酸对。结论是,大流行年份的可预测部分和不可预测部分之间的差异明显小于相邻年份的差异。此外,还证实了流感病毒HA / NA蛋白的突变将引起流感大流行。

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