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首页> 外文期刊>Journal of liposome research >Preparation and characterization of galactose-modified liposomes by a nonaqueous enzymatic reaction.
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Preparation and characterization of galactose-modified liposomes by a nonaqueous enzymatic reaction.

机译：通过非水酶促反应制备和鉴定半乳糖修饰的脂质体。

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摘要

In this study, NOH (NOH = N-octadecyl-4-[(D-galactopyranosyl)oxy]-2,3,5,6-tetrahydroxy hexanamide) was enzymatically synthesized as a targeting molecule and incorporated into liposomes to prepare a liposome surface modified with galactose. Glycyrrhetinic-acid-loaded liposome (GA-LP) and glycyrrhetinic-acid-loaded liposome surface modified with galactose (NOH-GA-LP) were prepared by the ethanol-injection method. NOH-GA-LP was characterized by morphology, particle size, zeta potential, encapsulation efficiency, release in vitro, and stability. The size of spherical particles was in the range of 179-211 nm. Spherical particles exhibit a positive electrical charge (38.7 mV) and possess high encapsulation efficiency (91.3%) and show sustained release (72% over 48 hours) in vitro. This novel approach for the liposome surface modified with galactose by enzymatic synthesis is expected to provide potential application as a drug carrier for active targeted delivery to hepatocytes.
机译：在这项研究中，酶促合成了NOH（NOH = N-十八烷基-4-[（D-吡喃半乳糖基）氧基] -2,3,5,6-四羟基己酰胺）作为靶向分子，并掺入脂质体中以制备脂质体表面用半乳糖修饰。通过乙醇注射法制备了载有甘草次酸的脂质体（GA-LP）和经半乳糖修饰的载有甘草次酸的脂质体（NOH-GA-LP）。 NOH-GA-LP的特征在于形态，粒径，ζ电位，包封效率，体外释放和稳定性。球形颗粒的尺寸在179-211nm的范围内。球形颗粒在体外显示出正电荷（38.7 mV），具有高封装效率（91.3％），并显示出持续释放（48小时内72％）。预期通过酶促合成用半乳糖修饰的脂质体表面的这种新方法将有望作为药物载体用于主动靶向递送至肝细胞。

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