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首页> 外文期刊>Journal of psychopharmacology >Neurobehavioural sequelae of social deprivation in rodents revisited: Modelling social adversity for developmental neuropsychiatric disorders
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Neurobehavioural sequelae of social deprivation in rodents revisited: Modelling social adversity for developmental neuropsychiatric disorders

机译：再次探讨啮齿类动物社交剥夺的神经行为后遗症：发展性神经精神疾病的社交逆境建模

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The significance of investigating effects of deprivation of social experience in rodents is reviewed in the context of the review by Robbins et al. (1996) in the Journal of Psychopharmacology (10: 39-47). The early development of the paradigm by which rats were reared post-weaning in social isolation is described and compared with other early experience manipulations. The specification of the neural and behavioural phenotype of the isolate is brought up-to-date, focusing on changes in motivation and cognitive function, as well as on contrasting changes in the dopamine and serotonin systems, and in cortical (including hippocampal) structure and function. The relevance of the isolate for animal models of psychiatric disorders such as attention deficit hyperactivity disorder and schizophrenia is reviewed, and it is considered that the paradigm best exemplifies a manipulation that can be applied to test effects of certain forms of social adversity during adolescence on brain development and behaviour.
机译：罗宾斯等人在综述的背景下，综述了剥夺啮齿动物社会经验影响的研究意义。 （1996）在Psychopharmacology杂志（10：39-47）中。描述了断奶后大鼠在社交隔离中饲养的范式的早期发展，并将其与其他早期体验操作进行了比较。该分离物的神经和行为表型的规范已更新，着重于动机和认知功能的变化，以及多巴胺和5-羟色胺系统以及皮质（包括海马）结构的对比变化。功能。审查了分离物与精神疾病如注意缺陷多动障碍和精神分裂症的动物模型的相关性，并且认为该范例最好地例证了一种可用于测试青春期对大脑的某些形式的社会逆境的影响的操作发展和行为。

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