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首页> 外文期刊>Journal of psychopharmacology >Reduction of ethanol intake by chronic treatment with Hypericum perforatum, alone or combined with naltrexone in rats.
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Reduction of ethanol intake by chronic treatment with Hypericum perforatum, alone or combined with naltrexone in rats.

机译：通过贯叶连翘单独或与纳曲酮联合长期治疗可减少大鼠乙醇摄入。

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Acute treatment with extracts of Hypericum perforatum, the common plant usually called St. John's Wort, reduces voluntary ethanol intake in Marchigian Sardinian alcohol-preferring (msP) rats and acts synergistically with opioid receptor antagonists to further attenuate ethanol consumption. The present study evaluated the effect of chronic (once a day for 12 days) intragastric administration of a CO(2) Hypericum perforatum extract (HPCO(2)), given alone or combined with naltrexone (NTX), on ethanol intake offered 2h/day in msP rats. Chronic treatment with HPCO(2) markedly reduced ethanol intake at the dose of 125, but not at 7mg/kg; the effect of 125mg/kg was observed since the first day of treatment and remained constant across the 12 days. The same dose of HPCO(2) slightly reduced the simultaneous intake of food only on day 3 and day 11 of treatment. Treated rats promptly recovered baseline ethanol intake when treatment did not precede access to ethanol (on day 8) or after the end of treatment (day 13and day 14), suggesting that HPCO(2) administrations did not induce conditioned aversion to alcohol. Chronic intraperitoneal treatment with NTX reduced ethanol intake at 3, but not at 0.5mg/kg. The synergistic effect on ethanol intake of HPCO(2) and NTX was evident also in conditions of chronic treatment. HPCO(2), 7mg/kg, and NTX, 0.5mg/kg, evoked a pronounced and statistically significant reduction of ethanol intake, while being inactive. The effect on ethanol intake of the combined treatment remained stable over the 12 days of treatment; food intake was slightly reduced only on day 3 and on day 7 in response to 125mg/kg of HPCO(2) combined with NTX 0.5mg/kg, but no difference in body weight between controls and treated rats was observed at the end of treatment. Following 12-day treatment with 125mg/kg of HPCO(2), no difference was observed in the responsivity of msP rats to the effect on ethanol intake of several doses of the extract. In conclusion, the present results provide evidence for a selective and pronounced effect of HPCO(2), alone or combined with naltrexone, on ethanol intake in conditions of chronic treatment, without development of tolerance. These findings further support the view that clinical trials for extracts of Hypericum perforatum in the treatment of alcoholism should be considered.
机译：贯叶连翘的提取物（通常被称为圣约翰草）的急性处理减少了马尔基希丁撒丁岛偏爱酒精（msP）大鼠的自愿乙醇摄入，并与阿片受体拮抗剂协同作用，进一步减少了乙醇的消耗。本研究评估了单独（或与纳曲酮（NTX）联合给予）CO（2）贯叶连翘提取物（HPCO（2））的慢性（每天一次，连续12天）对2h /小时乙醇摄入的影响。 msP大鼠的第一天。用HPCO（2）进行的慢性治疗可显着降低125剂量的乙醇摄入量，但不能降低7mg / kg的乙醇摄入量。从治疗的第一天开始观察到125mg / kg的作用，并且在整个12天内保持恒定。仅在治疗的第3天和第11天，相同剂量的HPCO（2）会稍微减少同时进食。当治疗未在接触乙醇之前（第8天）或治疗结束后（第13天和第14天），治疗后的大鼠迅速恢复了基线乙醇摄入量，这表明HPCO（2）给药不会诱发对酒精的条件性厌恶。 NTX慢性腹膜内治疗可减少3的乙醇摄入，但不能减少0.5mg / kg的乙醇摄入。在慢性治疗条件下，对HPCO（2）和NTX乙醇摄入的协同作用也很明显。 HPCO（2）（7mg / kg）和NTX（0.5mg / kg）引起乙醇摄入显着减少并具有统计学意义的显着减少，而无活性。联合治疗对乙醇摄入的影响在治疗的12天中保持稳定。仅在第3天和第7天，对125mg / kg的HPCO（2）与NTX 0.5mg / kg的结合，食物摄入量略有减少，但是在治疗结束时，对照组和治疗的大鼠之间没有体重差异。用125mg / kg的HPCO（2）处理12天后，msP大鼠对几种剂量的提取物对乙醇摄入的反应没有观察到差异。综上所述，本研究结果提供了在慢性治疗条件下单独或与纳曲酮合用的HPCO（2）对乙醇摄入的选择性和显着作用的证据，而没有耐受性的发展。这些发现进一步支持这样一种观点，即应考虑对贯叶连翘提取物治疗酒精中毒的临床试验。

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