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首页> 外文期刊>Journal of psychopharmacology >Memory function in women with premenstrual complaints and the effect of serotonergic stimulation by acute administration of an alpha-lactalbumin protein.
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Memory function in women with premenstrual complaints and the effect of serotonergic stimulation by acute administration of an alpha-lactalbumin protein.

机译：患有经前期症状的妇女的记忆功能以及通过急性给予α-乳白蛋白而引起的血清素能刺激作用。

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摘要

Serotonergic hypofunction may underlie at least part of the symptoms that are experienced by women with premenstrual complaints, including memory deficits. In the current study we investigated changes in memory functions in the premenstrual phase compared to the early postmenstrual phase in 16 women with premenstrual complaints. In addition, the effect of an acute serotonergic stimulation by administration of an alpha-lactalbumin protein on premenstrual memory performance was assessed using a double-blind placebo-controlled crossover design. It was found that both short-term and long-term memory for words (30-word learning task) and abstract figures (abstract visual learning task) were mildly impaired in the premenstrual phase. Administration of alpha-lactalbumin during the premenstrual phase could only partially attenuate the memory performance decrements that are seen in the premenstrual phase. Specifically, alphalactalbumin improved long-term memory for abstract figures, but not for words. There were no effects of menstrual phase or alpha-lactalbumin on planning functions (computerized Tower of London). The data suggest that serotonergic hypofunction may play a role in premenstrual memory decline, but serotonergic mechanisms cannot fully account for observed cognitive changes in the premenstrual phase.
机译：血清素能功能减退可能是经前期症状的女性所经历的症状的至少一部分，包括记忆缺陷。在本研究中，我们调查了16位经前期抱怨的女性与经后早期相比，经前阶段记忆功能的变化。另外，使用双盲安慰剂对照的交叉设计评估了通过施用α-乳白蛋白蛋白对急性血清素刺激的影响对经前记忆性能的影响。发现在经前阶段，单词的短期和长期记忆（30个单词的学习任务）和抽象图形（抽象的视觉学习任务）都会受到轻微的损害。在经前期服用α-乳清蛋白只能部分减弱经前期所见的记忆性能下降。具体而言，α乳白蛋白改善了对抽象图形的长期记忆，但对单词没有改善。月经期或α-乳白蛋白对计划功能（伦敦塔计算机化）没有影响。数据表明，血清素能低下可能在月经前记忆下降中起作用，但是血清素能机制不能完全解释月经期观察到的认知变化。

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