...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of psychopharmacology >Treatment of depression: time to consider folic acid and vitamin B12.
【24h】

Treatment of depression: time to consider folic acid and vitamin B12.

机译：抑郁症的治疗：时间考虑叶酸和维生素B12。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We review the findings in major depression of a low plasma and particularly red cell folate, but also of low vitamin B12 status. Both low folate and low vitamin B12 status have been found in studies of depressive patients, and an association between depression and low levels of the two vitamins is found in studies of the general population. Low plasma or serum folate has also been found in patients with recurrent mood disorders treated by lithium. A link between depression and low folate has similarly been found in patients with alcoholism. It is interesting to note that Hong Kong and Taiwan populations with traditional Chinese diets (rich in folate), including patients with major depression, have high serum folate concentrations. However, these countries have very low life time rates of major depression. Low folate levels are furthermore linked to a poor response to antidepressants, and treatment with folic acid is shown to improve response to antidepressants. A recent study also suggests that high vitamin B12 status may be associated with better treatment outcome. Folate and vitamin B12 are major determinants of one-carbon metabolism, in which S-adenosylmethionine (SAM) is formed. SAM donates methyl groups that are crucial for neurological function. Increased plasma homocysteine is a functional marker of both folate and vitamin B12 deficiency. Increased homocysteine levels are found in depressive patients. In a large population study from Norway increased plasma homocysteine was associated with increased risk of depression but not anxiety. There is now substantial evidence of a common decrease in serum/red blood cell folate, serum vitamin B12 and an increase in plasma homocysteine in depression. Furthermore, the MTHFR C677T polymorphism that impairs the homocysteine metabolism is shown to be overrepresented among depressive patients, which strengthens the association. On the basis of current data, we suggest that oral doses of both folic acid (800 microg daily) and vitamin B12 (1 mg daily) should be tried to improve treatment outcome in depression.
机译：我们回顾了血浆水平低，尤其是红细胞叶酸，维生素B12含量低的严重抑郁症的研究结果。在抑郁症患者的研究中发现低叶酸和低维生素B12的状态，在普通人群的研究中发现抑郁症与两种维生素的低水平之间存在关联。用锂治疗的复发性情绪障碍患者中也发现血浆或血清叶酸水平低。在酒精中毒患者中，抑郁症和低叶酸之间也存在相似的联系。有趣的是，香港和台湾的中国传统饮食（富含叶酸）人群，包括重度抑郁症患者，血清叶酸浓度很高。但是，这些国家的严重抑郁症的寿命很短。叶酸水平低还与对抗抑郁药的不良反应有关，显示叶酸治疗可改善对抗抑郁药的反应。最近的一项研究还表明，高维生素B12状态可能与更好的治疗效果相关。叶酸和维生素B12是一碳代谢的主要决定因素，其中会形成S-腺苷甲硫氨酸（SAM）。 SAM捐赠对神经功能至关重要的甲基。血浆高半胱氨酸水平升高是叶酸和维生素B12缺乏的功能标志。在抑郁症患者中发现同型半胱氨酸水平升高。在挪威进行的一项大规模人群研究中，血浆同型半胱氨酸水平升高与抑郁风险增加有关，但与焦虑症无关。现在有大量证据表明，抑郁症患者的血清/红细胞叶酸，血清维生素B12普遍减少，血浆高半胱氨酸水平增加。此外，在抑郁症患者中，损害同型半胱氨酸代谢的MTHFR C677T多态性被证明过高，从而加强了这种关联。根据当前数据，我们建议应尝试口服叶酸（每天800微克）和维生素B12（每天1毫克）以改善抑郁症的治疗效果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号