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首页> 外文期刊>Journal of liquid chromatography and related technologies >HPLC DETERMINATION OF ACYCLOVIR IN SKIN LAYERS AND PERCUTANEOUS PENETRATION SAMPLES
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HPLC DETERMINATION OF ACYCLOVIR IN SKIN LAYERS AND PERCUTANEOUS PENETRATION SAMPLES

机译：高效液相色谱法测定皮肤层和经皮穿刺样品中阿昔洛韦的含量

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摘要

The aim of this study was to develop a direct, simple, and rapid high performance liquid chromatographic (HPLC) method for the determination of acyclovir (ACV) after in vitro percutaneous permeation studies. Samples were chromatographed on a reversed phase encapped column 250 x 4 mm C_8 LiChrospher Select B. The phase mobile was a mixture of acetonitrile-ammonium acetate 0.05 M (1 :99, v/v) pH 6.5. Detection was at 252 nm and the run time was 12min. The limit of detection was 0.006mug/mL. The detector response was found to be linear in the concentration range 0.05 to 10mug/mL. This assay is a selective, sensitive, and reproducible method for the quantification of ACV in skin layers and in the receptor compartment of Frank-type diffusion cells after percutaneous permeation studies.
机译：这项研究的目的是开发一种直接，简单，快速的高效液相色谱（HPLC）方法，用于在体外经皮渗透研究后测定无环鸟苷（ACV）。样品在250 x 4 mm C_8 LiChrospher Select B反相色谱柱上进行色谱分离。流动相为乙腈-乙酸铵0.05 M（1:99，v / v）pH 6.5的混合物。检测在252 nm，运行时间为12分钟。检测下限为0.006mug / mL。发现检测器的响应在浓度范围为0.05至10mug / mL范围内是线性的。该测定是一种选择性，灵敏且可重现的方法，用于对经皮渗透研究后的皮肤层和Frank型扩散细胞的受体区中的ACV进行定量。

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