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首页> 外文期刊>Journal of liquid chromatography and related technologies >HPLC enantiomeric resolution of novel tetralone derivatives on cellulose and amylose based chiral stationary phases under normal phase mode
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HPLC enantiomeric resolution of novel tetralone derivatives on cellulose and amylose based chiral stationary phases under normal phase mode

机译：正相模式下纤维素和直链淀粉基手性固定相上新型四氢萘酮衍生物的HPLC对映体拆分

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摘要

A comparison of the enantiomeric resolution of several tetralone derivatives, which are 17< alpha >-hydroxylase/17,20-lyase (P450 17< alpha >) inhibitors has been achieved on different polysaccharides based chiral stationary phases, namely, Chiralcel OB, Chiralcel OD, Chiralpak AD, Chiralpak AS, and Chiralcel OF. The mobile phase used was hexane: ethanol: methanol (90: 7: 3 v/v/v) containing 0.5% triethylamine. Most of the compounds were completely separated on the polysaccharide based chiral stationary phases used in this study, with the exception of Chiralcel CA. The chromatographic parameters: the capacity factor (k), separation factor (< alpha >), and resolution factor (Rs) were calculated. The chiral recognition mechanisms between these analytes and chiral selectors are discussed.
机译：在不同的基于多糖的手性固定相上，即Chiralcel OB，Chiralcel，已对几种四氢萘酮衍生物的对映体拆分进行了比较，它们是17α-羟化酶/ 17,20-裂合酶（P45017α-）抑制剂OD，Chiralpak AD，Chiralpak AS和Chiralcel OF。所用的流动相是含有0.5％三乙胺的己烷：乙醇：甲醇（90：7：3 v / v / v）。除Chiralcel CA外，大多数化合物在用于本研究的基于多糖的手性固定相上被完全分离。计算色谱参数：容量因子（k），分离因子（）和分离因子（Rs）。讨论了这些分析物和手性选择剂之间的手性识别机理。

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