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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Complement activation in diabetic ketoacidosis and its treatment.
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Complement activation in diabetic ketoacidosis and its treatment.

机译：糖尿病酮症酸中毒的补体激活及其治疗。

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Recent studies support the presence of an inflammatory response during the treatment of diabetic ketoacidosis (DKA). The objectives of this study were to monitor the complement activation products C3a, C4a, Bb, and C5b-9 prior to, during, and after correction of DKA. All patients had increased levels of C3a at 6-8 h and 24 h (P < 0.05). C4a was increased in only one patient. Bb showed an upward trend at 6-8 h, and was significantly elevated at 24 h (P < 0.05); sC5b-9 was elevated in all patients prior to treatment or in the first 6-8 h of treatment. Results indicate that the alternative pathway may be the primary pathway of activation. These results extend the observation that both DKA and its treatment produce varying degrees of immunologic stress during the time when acute complications are most likely to occur.
机译：最近的研究支持在糖尿病性酮症酸中毒（DKA）治疗期间存在炎症反应。这项研究的目的是在校正DKA之前，期间和之后监测补体激活产物C3a，C4a，Bb和C5b-9。所有患者在6-8 h和24 h时C3a水平均升高（P <0.05）。仅一名患者的C4a升高。 Bb在6-8 h呈上升趋势，在24 h显着升高（P <0.05）;在治疗前或治疗的前6-8小时，所有患者的sC5b-9均升高。结果表明，替代途径可能是激活的主要途径。这些结果扩展了以下观察：在最有可能发生急性并发症的期间，DKA及其治疗都会产生不同程度的免疫应激。

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