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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Smoking influences the immunological architecture of the human larynx.
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Smoking influences the immunological architecture of the human larynx.

机译：吸烟会影响人喉的免疫学结构。

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摘要

Little is known about the effects of demographic and lifestyle factors on laryngeal mucosal immunology. Pinch biopsies of laryngeal mucosa were studied from 63 patients without laryngeal disease. Areas of positive staining for HLA-DR, HLA-DQ, HLA-DP, CD45, CD45RA, CD45RO, CD4, CD8, and CD79 were calculated. Patients were stratified according to gender and smoking status. Analysis of covariance showed current cigarette smokers had increased numbers of CD4+ T cells and there was an association between older age and greater CD4+ T cell numbers in both epithelium and lamina propria. Older age and female gender were associated with decreased lamina propria CD4+ CD45RO+ T cells and an increase in CD4+ CD45RO- T cells. T cell populations in the larynx may therefore be influenced by smoking, age and gender. We hypothesize that smoking induces changes in normal immunological function of the larynx, which may contribute to the etiology of inflammatory disease and cancer.
机译：关于人口统计学和生活方式因素对喉粘膜免疫学的影响知之甚少。对63例无喉疾病的患者进行了喉粘膜夹取活检。计算HLA-DR，HLA-DQ，HLA-DP，CD45，CD45RA，CD45RO，CD4，CD8和CD79阳性染色的面积。根据性别和吸烟状况对患者进行分层。协方差分析显示，目前的吸烟者的上皮和固有层中CD4 + T细胞数量增加，并且老年人与较高的CD4 + T细胞数量之间存在关联。老年和女性与固有层CD4 + CD45RO + T细胞减少和CD4 + CD45RO- T细胞增加相关。因此，吸烟，年龄和性别可能会影响喉咙中的T细胞种群。我们假设吸烟会引起喉咙正常免疫功能的改变，这可能有助于炎症性疾病和癌症的病因学。

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