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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >B cell reconstitution after rituximab treatment of lymphoma recapitulates B cell ontogeny.
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B cell reconstitution after rituximab treatment of lymphoma recapitulates B cell ontogeny.

机译：利妥昔单抗治疗淋巴瘤后的B细胞重建可概括B细胞的个体发育。

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摘要

The long-term immunologic effects of B cell depletion with rituximab and the characteristics of the reconstituting B cell pool in lymphoma patients are not well defined, despite the widespread usage of this therapy. Here we report that during the B cell reconstitution phase a majority of the peripheral blood B cells have an immature transitional phenotype (47.8%+/-25.2% vs. 4.4%+/-2.4% for normal controls, p<0.0001), similar to what has been described during the original ontogeny of the immune system and following bone marrow transplantation. Moreover, the recovery of the CD27+ memory B cell pool was delayed compared to normal B cell ontogeny, remaining below normal controls at 1 year post-rituximab (4.4%+/-3% vs. 31%+/-7%, p<0.0001). Expansion of functionally immature B cells and decreased memory B cells may contribute to an immunodeficient state in patients recovering from rituximab mediated B cell depletion, particularly with repeated treatment.
机译：尽管淋巴瘤患者广泛使用了利妥昔单抗，但其长期的免疫学作用和重组B细胞池的特征尚不清楚。在这里，我们报道在B细胞重构阶段，大多数外周血B细胞具有不成熟的过渡表型（47.8％+ /-25.2％，而正常对照组为4.4％+ /-2.4％，p <0.0001），相似与免疫系统最初的个体发育过程中以及骨髓移植后的描述相同。此外，与正常B细胞​​个体发育相比，CD27 +记忆B细胞池的恢复被延迟，在利妥昔单抗治疗1年后仍低于正常对照（4.4％+ /-3％对31％+ /-7％，p < 0.0001）。在从利妥昔单抗介导的B细胞耗竭中康复的患者中，功能上不成熟的B细胞的扩增和记忆B细胞的减少可能导致免疫缺陷状态，尤其是反复治疗时。

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