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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo.
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The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo.

机译：ALV003预先消化的面筋对体内腹腔疾病的免疫反应和症状的影响。

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摘要

Effective treatment of celiac disease is an unmet medical need. A glutenase that destroys immunogenic gluten peptides may be clinically valuable. Twenty patients with celiac disease were randomly assigned to ingest a large gluten meal (16 g daily for 3 days) pre-treated with ALV003, a mixture of highly specific glutenases (n=10), or pre-treated with placebo (n=10). Peripheral blood T-cell IFN-gamma ELISpot responses to gliadin and an immunogenic 33mer and symptoms were assessed. While baseline IFN-gamma ELISpot responses to gliadin and the 33mer were negative in all patients, a significant ELISpot response to gliadin or the 33mer was observed in 6 of 10 patients consuming placebo-treated gluten and 0 of 10 consuming ALV003 pre-treated gluten (p=0.011). Symptoms typically associated with gluten ingestion occurred in both groups and were not significantly reduced by ALV003 pre-treatment. ALV003 pre-treatment can abolish immune responses induced by gluten in patients with celiac disease.
机译：有效治疗腹腔疾病是尚未满足的医学需求。破坏免疫原性麸质肽的谷蛋白酶可能具有临床价值。随机分配20名腹腔疾病患者，以ALV003，高特异性谷氨酸酶混合物（n = 10）预先治疗或以安慰剂（n = 10）预先治疗摄入大面筋粉（每天16 g，共3天） ）。评估了对麦醇溶蛋白和免疫原性33mer的外周血T细胞IFN-γELISpot反应和症状。尽管在所有患者中对麦醇溶蛋白和33mer的基线IFN-γELISpot反应均为阴性，但在接受安慰剂治疗的面筋的10例患者中有6例和接受ALV003预处理的面筋的10例中有0例观察到对麦醇溶蛋白或33mer的显着ELISpot反应（ p ＝ 0.011）。两组中通常都发生与麸质摄入有关的症状，ALV003预处理并没有明显减轻这些症状。 ALV003预处理可以消除麸质患者的麸质诱导的免疫反应。

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