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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Human memory-like NK cells migrating to tuberculous pleural fluid via IP-10/CXCR3 and SDF-1/CXCR4 axis produce IFN-γ in response to Bacille Calmette Guerin
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Human memory-like NK cells migrating to tuberculous pleural fluid via IP-10/CXCR3 and SDF-1/CXCR4 axis produce IFN-γ in response to Bacille Calmette Guerin

机译：经由IP-10 / CXCR3和SDF-1 / CXCR4轴迁移至结核性胸膜液的类人记忆性NK细胞响应Bacille Calmette Guerin产生IFN-γ

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We have previously shown that human memory-like NK cells were persistent in tuberculous pleurisy but it was unclear how NK cells migrated into the pleural fluids. At present, we found that NK cells from TB pleural fluid cells (PFCs) expressed significantly higher levels of CXCR3 and CXCR4 than NK cells from PBMCs. Migration assay demonstrated that IP-10 and SDF-1 induced more migration of NK cells from PFCs than PBMCs. CD45RO+ or CD45RO- NK cells from PFCs were co-cultured with autologous monocytes and stimulated with BCG. The results showed CD45RO+ but not CD45RO- NK cells produced significantly higher levels of IFN-γ, which was IL-12-dependent since anti-IL-12Rβ1 mAbs could significantly inhibit the IFN-γ by NK cells. Collectively, our data demonstrated that human Mycobacterium tuberculosis-specific NK cells were migrated into the local site of TB infection mainly via IP-10/CXCR3 and SDF-1/CXCR4 axis, memory-like NK cells might display an important role against M. tuberculosis infection.
机译：先前我们已经表明，人类记忆样NK细胞在结核性胸膜炎中持续存在，但尚不清楚NK细胞如何迁移到胸膜液中。目前，我们发现TB胸膜液细胞（PFC）的NK细胞表达的CXCR3和CXCR4水平明显高于PBMC的NK细胞。迁移分析表明，IP-10和SDF-1比PBMC诱导更多的PFC NK细胞迁移。将来自PFC的CD45RO +或CD45RO-NK细胞与自体单核细胞共培养并用BCG刺激。结果显示，CD45RO +而非CD45RO-NK细胞产生的IFN-γ水平明显升高，这是IL-12依赖性的，因为抗IL-12Rβ1mAbs可以显着抑制NK细胞的IFN-γ。总体而言，我们的数据表明，人类结核分枝杆菌特异性NK细胞主要通过IP-10 / CXCR3和SDF-1 / CXCR4轴迁移到了结核感染的本地部位，类似记忆的NK细胞可能对M具有重要作用。结核感染。

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