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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >CD52 is a novel costimulatory molecule for induction of CD4+ regulatory T cells.
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CD52 is a novel costimulatory molecule for induction of CD4+ regulatory T cells.

机译：CD52是用于诱导CD4 +调节性T细胞的新型共刺激分子。

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摘要

We previously reported that 4C8 monoclonal antibody (mAb) provides a costimulatory signal to human CD4+ T cells and consequently induces regulatory T (Treg) cells, which are hypo-responsive and suppress the polyclonal response of bystander CD4+ cells in a contact-dependent manner. In this study, we identified the antigen of 4C8 mAb as CD52. Costimulation with Campath-1H, a humanized anti-CD52 mAb, also induced Treg cells. Anti-CD52-induced Treg cells suppressed the proliferation of both CD4+ and CD8+ T cells provided with polyclonal or allogeneic stimulation. When Treg cells were induced from Staphylococcal enterotoxin B (SEB) treated cells, they suppressed the response to SEB more efficiently than that to another superantigen, SEA. Furthermore, anti-CD52-induced Treg cells could be expanded by culture with IL-2 followed by CD52-costimulation, and co-injection of expanded Treg cells suppressed lethal xenogeneic graft versus host disease (GvHD) reactions in SCID mice caused by human peripheral blood mononuclear cells (PBMCs).
机译：我们先前曾报道4C8单克隆抗体（mAb）向人CD4 + T细胞提供共刺激信号，因此诱导了调节性T（Treg）细胞，后者反应低下并以接触依赖的方式抑制旁观者CD4 +细胞的多克隆反应。在这项研究中，我们鉴定了4C8 mAb的抗原为CD52。与人源化抗CD52 mAb Campath-1H共刺激，也可诱导Treg细胞。抗CD52诱导的Treg细胞抑制了多克隆或同种异体刺激提供的CD4 +和CD8 + T细胞的增殖。当从葡萄球菌肠毒素B（SEB）处理的细胞中诱导Treg细胞时，与对另一种超抗原SEA的反应相比，它们更有效地抑制了对SEB的反应。此外，抗CD52诱导的Treg细胞可通过与IL-2一起培养，然后进行CD52共刺激而扩增，并且共同注射扩增的Treg细胞可抑制人外周血引起的SCID小鼠致死性异种移植物抗宿主病（GvHD）反应血液单核细胞（PBMC）。

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