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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Reassessing the role of growth hormone and sex steroids in thymic involution.
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Reassessing the role of growth hormone and sex steroids in thymic involution.

机译：重新评估生长激素和性类固醇在胸腺退化中的作用。

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The concomitant decline in growth hormone (GH) and increase in sex steroid production with age is thought to be responsible for thymic involution. If changes in the production of these hormones trigger or sustain thymic involution, that process should be accelerated in little mice, which have a genetic deficiency resulting in reduced production of thymopoietic GH, and delayed in the hypogonadal strain, which fails to produce thymocytotoxic sex steroids. The results indicated that thymic involution in both strains progressed in a manner similar to their normal littermates. That blocking sex steroid production did not delay thymic involution was surprising since castration reportedly increases thymus cellularity. Re-examination of that phenomenon revealed that, while gonadectomy results in increased thymus size, its effects are transient, and the thymus ultimately undergoes involution. Taken together, these data suggest that age-related changes in the endocrine system do not underlie thymic involution.
机译：随着年龄的增长，伴随着生长激素（GH）的下降和性类固醇生成的增加被认为是胸腺退化的原因。如果这些激素产生的变化触发或维持胸腺退化，应在具有遗传缺陷导致胸腺生成激素减少的小小鼠中加速该过程，并延缓性腺机能减退，从而不能产生胸腺细胞毒性性类固醇。结果表明，两种菌株的胸腺退化都以与其正常同窝仔相似的方式进行。阻止性类固醇生成不会延迟胸腺退化，这是令人惊讶的，因为据报道cast割会增加胸腺的细胞性。对这一现象的重新检查表明，尽管性腺切除术会导致胸腺增大，但其作用是短暂的，最终胸腺会退化。综上所述，这些数据表明内分泌系统中与年龄相关的变化并不是胸腺退化的基础。

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