• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Function and recruitment of mucosal regulatory T cells in human chronic Helicobacter pylori infection and gastric adenocarcinoma.
【24h】

Function and recruitment of mucosal regulatory T cells in human chronic Helicobacter pylori infection and gastric adenocarcinoma.

机译：黏膜调节性T细胞在人慢性幽门螺杆菌感染和胃腺癌中的功能和募集。

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

CD4(+)CD25(high) FOXP3-expressing regulatory T cells (Treg) can suppress immune responses to infections and tumors, thereby promoting microbial persistence and tumor progression. However, little is known about the phenotype and function of human mucosal Treg. Therefore, we analyzed the suppressive activity and homing phenotype of Treg in gastric mucosa of Helicobacter pylori-infected gastric adenocarcinoma patients. We found increased numbers of CD4(+)FOXP3(+) Treg in the tumor compared to tumor-free gastric mucosa. Gastric Treg cells were able to suppress H. pylori-induced T cell proliferation and IFN-gamma production. Furthermore, gastric Treg expressed increased levels of l-selectin and CCR4, compared to non-Treg cells, suggesting that these receptors contribute to Treg recruitment. The presence of functional antigen-specific Treg in H. pylori-infected gastric mucosa supports an important role for these cells in suppression of mucosal effector T cell responses, which probably contribute to bacterialpersistence and possibly also to gastric tumor progression.
机译：表达CD4（+）CD25（高）FOXP3的调节性T细胞（Treg）可以抑制对感染和肿瘤的免疫反应，从而促进微生物的持久性和肿瘤的进展。然而，关于人类粘膜Treg的表型和功能知之甚少。因此，我们分析了幽门螺杆菌感染的胃腺癌患者胃黏膜中Treg的抑制活性和归巢表型。我们发现与无肿瘤的胃粘膜相比，肿瘤中CD4（+）FOXP3（+）Treg的数量增加。胃Treg细胞能够抑制幽门螺杆菌诱导的T细胞增殖和IFN-γ产生。此外，与非Treg细胞相比，胃Treg表达的l-选择蛋白和CCR4水平升高，表明这些受体有助于Treg募集。幽门螺杆菌感染的胃粘膜中功能性抗原特异性Treg的存在为这些细胞在抑制粘膜效应T细胞反应中发挥了重要作用，这可能有助于细菌的持久性，还可能促进胃肿瘤的进展。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号