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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Identification of insulin autoantibodies of IgA isotype that preferentially target non-human insulin.
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Identification of insulin autoantibodies of IgA isotype that preferentially target non-human insulin.

机译：鉴定优先针对非人胰岛素的IgA同种型胰岛素自身抗体。

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摘要

Insulin autoantibodies (IAA) precede clinical type 1 diabetes in children. Immunization events leading to IAA are unknown. The aim of this study was to determine whether some IAA result from mucosal immunization. IgA-IAA and binding of IAA to non-human insulin were examined in selected high and low affinity IAA-positive samples and in first IAA-positive samples from children aged <2 years. High affinity IAA (>10(9)L/mol) bound strongly to human insulin and poorly to chicken insulin. In contrast, 12/13 lower affinity IAA were chicken insulin-reactive, binding equally to human and chicken insulin (n=4), or preferentially binding chicken insulin (n=8). IgA-IAA were found in association with chicken insulin-reactive IAA, and included cases where IgA-IAA predominated over IgG-IAA. Among 20 IAA-positive children aged <2 years, one had early IgA-chicken insulin-reactive IAA that were replaced by high affinity IgG-IAA. The findings suggest that some IAA can result from immunization against molecules other thanhuman insulin at mucosal sites.
机译：儿童的临床自身1型糖尿病先于胰岛素自身抗体（IAA）。导致IAA的免疫事件尚不清楚。这项研究的目的是确定某些IAA是否来自粘膜免疫。在选自2岁以下儿童的高亲和力和低亲和力IAA阳性样品以及首批IAA阳性样品中检查了IgA-IAA和IAA与非人胰岛素的结合。高亲和力IAA（> 10（9）L / mol）与人胰岛素牢固结合，而与鸡胰岛素结合不良。相反，低亲和力IAA的12/13是鸡胰岛素反应性的，与人和鸡胰岛素均等结合（n = 4），或优先结合鸡胰岛素（n = 8）。发现IgA-IAA与鸡胰岛素反应性IAA相关，并且包括IgA-IAA高于IgG-IAA的病例。在20名2岁以下的IAA阳性儿童中，有1名早期IgA鸡胰岛素反应性IAA被高亲和力IgG-IAA取代。研究结果表明，在粘膜部位针对人胰岛素以外的分子进行免疫接种可产生某些IAA。

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