...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of psychiatric research >Brain and behavioral evidence for altered social learning mechanisms among women with assault-related posttraumatic stress disorder
【24h】

Brain and behavioral evidence for altered social learning mechanisms among women with assault-related posttraumatic stress disorder

机译：攻击相关的创伤后应激障碍女性的社会学习机制改变的大脑和行为证据

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Current neurocircuitry models of PTSD focus on the neural mechanisms that mediate hypervigilance for threat and fear inhibition/extinction learning. Less focus has been directed towards explaining social deficits and heightened risk of revictimization observed among individuals with PTSD related to physical or sexual assault. The purpose of the present study was to foster more comprehensive theoretical models of PTSD by testing the hypothesis that assault-related PTSD is associated with behavioral impairments in a social trust and reciprocity task and corresponding alterations in the neural encoding of social learning mechanisms. Adult women with assault-related PTSD (n = 25) and control women (n = 15) completed a multi-trial trust game outside of the MRI scanner. A subset of these participants (15 with PTSD and 14 controls) also completed a social and non-social reinforcement learning task during 3T fMRI. Brain regions that encoded the computationally modeled parameters of value expectation, prediction error, and volatility (i.e., uncertainty) were defined and compared between groups. The PTSD group demonstrated slower learning rates during the trust game and social prediction errors had a lesser impact on subsequent investment decisions. PTSD was also associated with greater encoding of negative expected social outcomes in perigenual anterior cingulate cortex and bilateral middle frontal gyri, and greater encoding of social prediction errors in the left temporoparietal junction. These data suggest mechanisms of PTSD-related deficits in social functioning and heightened risk for re-victimization in assault victims; however, comorbidity in the PTSD group and the lack of a trauma-exposed control group temper conclusions about PTSD specifically. (C) 2015 Elsevier Ltd. All rights reserved.
机译：当前PTSD的神经回路模型集中在介导针对警告和恐惧抑制/消灭学习的超警觉的神经机制。较少关注的重点是解释在与身体或性侵犯有关的PTSD患者中观察到的社会缺陷和重新受害的风险增加。本研究的目的是通过检验以下假设来建立更全面的PTSD理论模型：与攻击相关的PTSD与社会信任和互惠任务中的行为障碍以及社会学习机制的神经编码中的相应变化相关的假设。患有与攻击有关的PTSD的成年女性（n = 25）和对照女性（n = 15）在MRI扫描仪之外完成了一次多试信任游戏。这些参与者的一部分（15名患有PTSD，14名对照组）也在3T fMRI期间完成了社交和非社交强化学习任务。定义了编码期望值，预测误差和波动性（即不确定性）的计算模型化参数的大脑区域，并在各组之间进行了比较。 PTSD小组证明了在信任博弈中学习速度较慢，社交预测错误对后续投资决策的影响较小。创伤后应激障碍还与周围性前扣带回皮层和双侧中额回中负期望社会结局的更大编码以及左颞颞叶交界处社会预测误差的更大编码有关。这些数据表明，与创伤后应激障碍相关的社会功能缺陷的机制以及攻击受害者再次受害的风险增加;但是，PTSD组的合并症和缺乏创伤暴露的对照组对PTSD缺乏明确的结论。 （C）2015 Elsevier Ltd.保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号