• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Immune suppression via IL-4/IL-10-secreting T cells: a nontoxic property of anti-HIV agent trichosanthin.
【24h】

Immune suppression via IL-4/IL-10-secreting T cells: a nontoxic property of anti-HIV agent trichosanthin.

机译：通过分泌IL-4 / IL-10- T细胞的免疫抑制：抗HIV药剂天花粉蛋白的无毒特性。

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The activity of Trichosanthin (Tk) has been attributed to its toxicity since this plant protein was used as an anti-HIV agent. However, in this study strong inhibition of human lymphoproliferation to soluble and allogeneic antigens was induced by Tk at 0.005-0.5 microg/ml without causing cell damages including apoptosis. The suppression was dependent on the presence of monocytes that are able to internalize and process Tk molecules as exogenous antigens. Among 39 Tk-primed T cell lines established, those with strong suppressive activity were CD8(+) TCRalphabeta(+) with type 2 cytokine secretion profile. Depletion of CD8 cells from total T cells or blocking expression of HLA-DQ molecules diminished Tk's inhibitory activity. In addition, healthy subjects with HLA haplotype DRB1*0301-DQA1*0501-DQB1*0201 were susceptible to the hyporeaction induced by Tk or a Tk-derived peptide. This indicates that Tk could induce an HLA-associated immune suppression via activating IL-4/IL-10-secreting T cells, which mightbelong to CD8 Tc2 subset.
机译：天花粉蛋白（Tk）的活性归因于其毒性，因为该植物蛋白被用作抗HIV剂。然而，在这项研究中，Tk以0.005-0.5 microg / ml的浓度诱导了人类淋巴细胞对可溶性和同种异体抗原的强烈抑制，而没有引起包括细胞凋亡在内的细胞损伤。抑制取决于能够将Tk分子内化并加工为外源抗原的单核细胞的存在。在建立的39个由Tk启动的T细胞系中，具有强烈抑制活性的是具有2型细胞因子分泌特征的CD8（+）TCRalphabeta（+）。总T细胞中CD8细胞的耗竭或HLA-DQ分子的表达受阻降低了Tk的抑制活性。另外，具有HLA单倍型DRB1 * 0301-DQA1 * 0501-DQB1 * 0201的健康受试者易受Tk或Tk衍生肽诱导的反应不足。这表明Tk可以通过激活IL-4 / IL-10-分泌的T细胞来诱导HLA相关的免疫抑制，该细胞可能属于CD8 Tc2亚群。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号