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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Shift of CMV-specific CD4+ T-cells to the highly differentiated CD45RO-CD27- phenotype parallels loss of proliferative capacity and precedes progression to HIV-related CMV end-organ disease.
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Shift of CMV-specific CD4+ T-cells to the highly differentiated CD45RO-CD27- phenotype parallels loss of proliferative capacity and precedes progression to HIV-related CMV end-organ disease.

机译：CMV特异的CD4 + T细胞向高分化CD45RO-CD27-表型的转移与增殖能力的丧失平行，并提前发展为HIV相关的CMV终末器官疾病。

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摘要

To identify factors related to progression to CMV end-organ disease, cytokine production, proliferative capacity and phenotype of CMV-specific CD4(+) T-cells were analysed longitudinally. Numbers of IFNgamma(+)CD4(+) and IFNgamma(+)IL-2(+)CD4(+) T-cells tended to decrease in individuals progressing to AIDS with CMV end-organ disease (AIDS-CMV), whereas they remained detectable in long-term asymptomatics (LTAs) and progressors to AIDS with opportunistic infections (AIDS-OI). In parallel, CMV-specific proliferative capacity was lost in AIDS-CMV. Initially, the majority of the CMV-specific IFNgamma(+)CD4(+) T-cells were of the CD45RO(+)CD27(-) subset, but during progression to AIDS-CMV a shift in phenotype to the CD45RO(-)CD27(-) subset was observed. Our data indicate that a decrease in CMV-specific cytokine production and proliferative capacity precedes progression to AIDS-CMV. Accumulation of CD4(+) T-cells with a CD45RO(-)CD27(-) phenotype suggests that persistent antigen exposure drives differentiation of CMV-specific CD4(+) T-cells towards a poorly proliferating, and highly differentiated "effector" subset, which eventually fails to produce IFNgamma in patients developing AIDS-CMV.
机译：为了确定与CMV终末器官疾病进展相关的因素，纵向分析了CMV特异性CD4（+）T细胞的细胞因子产生，增殖能力和表型。在患有患有CMV端器官疾病（AIDS-CMV）的艾滋病患者中，IFNgamma（+）CD4（+）和IFNgamma（+）IL-2（+）CD4（+）T细胞的数量趋于减少。在长期无症状（LTA）和机会感染性艾滋病（AIDS-OI）的进展中仍然可以检测到。同时，在AIDS-CMV中失去了CMV特异的增殖能力。最初，大多数CMV特异性IFNgamma（+）CD4（+）T细胞属于CD45RO（+）CD27（-）子集，但在发展为AIDS-CMV的过程中，表型向CD45RO（-）转移。观察到CD27（-）子集。我们的数据表明，CMV特异性细胞因子的产生和增殖能力的下降先于艾滋病-CMV的发展。具有CD45RO（-）CD27（-）表型的CD4（+）T细胞的积累表明，持续的抗原暴露驱使CMV特异性CD4（+）T细胞分化为增殖不良和高度分化的“效应子”亚群，最终在发展为AIDS-CMV的患者中不产生IFNgamma。

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