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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Circulating levels of TNF-like cytokine 1A (TL1A) and its decoy receptor 3 (DcR3) in rheumatoid arthritis.
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Circulating levels of TNF-like cytokine 1A (TL1A) and its decoy receptor 3 (DcR3) in rheumatoid arthritis.

机译：类风湿关节炎中TNF-样细胞因子1A（TL1A）及其诱饵受体3（DcR3）的循环水平。

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摘要

TL1A is a novel TNF-like cytokine, which provides co-stimulatory and Th1-polarizing signals to activated lymphocytes, via binding to death-domain receptor 3 (DR3). These functions are inhibited when TL1A associates to decoy receptor 3 (DcR3). We investigated the serum expression of TL1A and DcR3 in 81 patients with RA and 51 healthy controls. TL1A concentrations were elevated in patients by 5-fold (P<0.00001). This increase was more prominent in RFactor-positive patients and correlated with clinical activity in this subgroup. DcR3 was detected more frequently and in significantly higher values in RA-derived sera, correlated strongly with TL1A, and was present in inflammatory synovial fluid. Severe RA stage was associated with highly elevated TL1A and DcR3 serum levels. Treatment with an anti-TNF agent significantly decreased TL1A serum levels. We conclude that TL1A may serve as an inflammatory marker in RA. Interactions between TL1A and its receptors may be important in the pathogenesis of RA.
机译：TL1A是一种新型的TNF样细胞因子，通过与死亡域受体3（DR3）结合，向活化的淋巴细胞提供共刺激信号和Th1极化信号。当TL1A与诱饵受体3（DcR3）结合时，这些功能被抑制。我们调查了81例RA患者和51例健康对照者的TL1A和DcR3血清表达。患者中的TL1A浓度升高了5倍（P <0.00001）。在RFactor阳性患者中，这种增加更为显着，并且与该亚组的临床活动相关。在源自RA的血清中检测到DcR3的频率更高，且值明显更高，与TL1A密切相关，并存在于炎性滑液中。严重的RA分期与高度升高的TL1A和DcR3血清水平有关。用抗TNF剂治疗可显着降低TL1A血清水平。我们得出结论，TL1A可能是RA中的炎症标志物。 TL1A及其受体之间的相互作用可能在RA的发病机制中很重要。

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