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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Association of the CTLA-4 gene with Vogt-Koyanagi-Harada syndrome.
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Association of the CTLA-4 gene with Vogt-Koyanagi-Harada syndrome.

机译：CTLA-4基因与Vogt-Koyanagi-Harada综合征的关联。

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摘要

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), a critical negative regulator of the T cell response, has been shown to be associated with a variety of autoimmune diseases. In this study, we investigated the association of CTLA-4 gene polymorphisms (- 1661A/G; - 318C/T; + 49G/A, and CT60) with Vogt-Koyanagi-Harada (VKH) syndrome in Chinese Han patients and normal controls. The results showed that the frequency of the G allele at the + 49 site was significantly higher in VKH patients than that observed in healthy controls (71.6% versus 62.8%, P = 0.0046, Pc = 0.037). Three haplotypes were identified from the four SNPs. The frequency of haplotype - 1661A:- 318C:+ 49G:CT60G, the most prevalent haplotype both in patients and controls, was significantly higher in patients than that in controls (70.1% versus 60.0%, P= 0.0013, n= 16, Pc = 0.021). These results suggest that CTLA-4 genetic polymorphisms are associated with the susceptibility to VKH syndrome.
机译：细胞毒性T淋巴细胞相关抗原4（CTLA-4）是T细胞应答的关键负调控因子，已显示与多种自身免疫性疾病相关。在这项研究中，我们调查了中国汉族患者和正常对照者的CTLA-4基因多态性（-1661A / G;-318C / T; + 49G / A和CT60）与Vogt-Koyanagi-Harada（VKH）综合征的相关性。结果显示，VKH患者+49位点的G等位基因频率显着高于健康对照者（71.6％对62.8％，P = 0.0046，Pc = 0.037）。从四个SNP中鉴定出三个单倍型。单倍型频率-1661A：-318C：+ 49G：CT60G是患者和对照组中最普遍的单倍型，患者的频率明显高于对照组（70.1％对60.0％，P = 0.0013，n = 16，Pc = 0.021）。这些结果表明，CTLA-4基因多态性与VKH综合征的易感性有关。

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