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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Impact of estrogen receptor deficiency on disease expression in the NZM2410 lupus prone mouse.
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Impact of estrogen receptor deficiency on disease expression in the NZM2410 lupus prone mouse.

机译：NZM2410狼疮易感小鼠中雌激素受体缺乏对疾病表达的影响。

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Systemic lupus erythematosus (SLE) occurs nine times more often in females than males. The purpose of this study was to determine the impact of estrogen receptor (ER) null genotypes on disease in lupus prone NZM2410 (NZM) and MRL/lpr mice, as a method to define the role of estrogen receptor signaling in lupus. ER alpha deficient NZM females, but not males, had significantly prolonged survival, reduced proteinuria, renal pathology scores and serum urea nitrogen levels compared to wildtype mice, despite higher serum anti-dsDNA levels. ER alpha deficient MRL/lpr female, but not male, mice also had significantly less proteinuria and renal pathology scores with no effect on autoantibody levels. Deficiency of ER beta had no effect on disease in either strain or sex. Taken together, these data demonstrate a key role for ER alpha, but not ER beta, in the development of lupus like disease, but not autoimmunity, in female NZM and MRL/lpr mice.
机译：女性的系统性红斑狼疮（SLE）的发生频率是男性的9倍。这项研究的目的是确定雌激素受体（ER）无效基因型对易患狼疮的NZM2410（NZM）和MRL / lpr小鼠疾病的影响，作为定义雌激素受体信号在狼疮中的作用的方法。尽管血清抗dsDNA水平较高，但与野生型小鼠相比，ERα缺乏的NZM雌性动物（而非雄性动物）具有明显延长的生存期，降低的蛋白尿，肾脏病理评分和血清尿素氮水平。雌性但非雄性的ER alpha缺陷型MRL / lpr小鼠的蛋白尿和肾脏病理评分也显着降低，并且对自身抗体水平没有影响。 ERβ缺乏对品系或性别的疾病均无影响。综上所述，这些数据证明雌性NZM和MRL / lpr小鼠在狼疮样疾病的发展中发挥了关键作用，但不是ER beta发挥了关键作用。

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