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首页> 外文期刊>Clinical immunology: The official journal of the Clinical Immunology Society >Distinct subsets of regulatory T cells during pregnancy: is the imbalance of these subsets involved in the pathogenesis of preeclampsia?
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Distinct subsets of regulatory T cells during pregnancy: is the imbalance of these subsets involved in the pathogenesis of preeclampsia?

机译：怀孕期间调节性T细胞的不同亚群：这些亚群的失衡是否与先兆子痫的发病机理有关？

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摘要

Regulatory T cells (CD4(+)CD25(+)FoxP3(+)-Treg cells) are important regulators of tolerance induction during pregnancy. We now found that the number of CD4(+)CD25(+)FoxP3(+)-Treg cells decreases during normal course of pregnancy and even more so in women affected by preeclampsia. The functional activity of these CD4(+)CD25(+)-Treg cells was significantly reduced in comparison to those of healthy pregnants. Further analysis revealed two Treg subsets that differed with regard to the FoxP3 and CD25 expression. The percentage of both, CD4(+)CD25(+)FoxP3(high+)-Treg and CD4(+)CD25(high+)FoxP3(+), was maximal in the first and second trimenon, but declined severely in the third trimenon. In preeclamptic women the population of CD4(+)CD25(high+)FoxP3(+)-Treg cells was particularly apparent, while the population of CD4(+)CD25(+)FoxP3(high+)-Treg cells was significantly decreased. We propose that CD4(+)CD25(+)FoxP3(high+)- and CD4(+)CD25(high+)FoxP3(+)-Treg cell populations represent distinct Treg cell subsets, and that disturbances in the balance of these two Treg cell subsets are associated with the presence of preeclampsia, but not HELLP-syndrome.
机译：调节性T细胞（CD4（+）CD25（+）FoxP3（+）-Treg细胞）是妊娠期间耐受性诱导的重要调节剂。现在，我们发现在正常妊娠过程中CD4（+）CD25（+）FoxP3（+）-Treg细胞的数量减少，而在先兆子痫患者中则更多。与健康孕妇相比，这些CD4（+）CD25（+）-Treg细胞的功能活性明显降低。进一步的分析表明，两个Treg亚型在FoxP3和CD25表达方面有所不同。 CD4（+）CD25（+）FoxP3（high +）-Treg和CD4（+）CD25（high +）FoxP3（+）的百分比在第一个和第二个三聚体中最大，但在第三个三聚体中严重下降。在先兆子痫妇女中，CD4（+）CD25（high +）FoxP3（+）-Treg细胞的数量特别明显，而CD4（+）CD25（+）FoxP3（high +）-Treg细胞的数量则明显减少。我们建议CD4（+）CD25（+）FoxP3（high +）-和CD4（+）CD25（high +）FoxP3（+）-Treg细胞群体代表不同的Treg细胞亚群，并且这两个Treg细胞的平衡受到干扰子集与先兆子痫的存在有关，但与HELLP综合征无关。

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